PMID: 7025155Mar 1, 1981

Some observations on the pneumococcus and on the current status of pneumococcal disease and its prevention

Reviews of Infectious Diseases
R Austrian


Although the means whereby pneumococcus damages the hosts it invades remain unknown, some advances in understanding the biology of this organism and the pathogenesis of pneumococcal infection have been made in recent years. Knowledge of the composition of the cell wall (C) polysaccharide of the pneumococcus and its relation to the capsular polysaccharides of this organism is considered and a hypothesis of the evolution of the pneumococcal capsule is entertained. Refinements in understanding the pathogenesis of pneumococcal pneumonia, bacteremia, and otitis media are reviewed, and current knowledge of the epidemiology of pneumococcal infections and of the distribution of pneumococcal types causing such infections is discussed. The history of the development of pneumococcal vaccines is summarized briefly, together with an account of the field trials of contemporary polyvalent vaccines of pneumococcal capsular polysaccharides conducted recently.


Nov 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G A Bruyn, R van Furth
Oct 1, 1983·European Journal of Clinical Microbiology·J H BraconierH Odeberg
Oct 1, 1983·European Journal of Clinical Microbiology·S Bergner-RabinowitzJ Michel
May 31, 2008·Current Infectious Disease Reports·Catherine Lexau
May 20, 2004·Vaccine·Debby BogaertR de Groot
Mar 18, 2000·International Journal of Antimicrobial Agents·M A Mufson
Dec 7, 2002·The Lancet Infectious Diseases·Uwe KoedelHans-Walter Pfister
Mar 8, 1984·The New England Journal of Medicine·R Austrian
Jul 26, 1984·The New England Journal of Medicine·J H Lutschg
May 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·J K MoronaJ C Paton
Apr 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J C PatonR Morona
Oct 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·U B Sørensen, J Blom
Jan 1, 1994·Equine Veterinary Journal·A S BlundenJ A Mumford
Apr 15, 2003·Clinical Microbiology Reviews·Andrew S ArtzDan L Longo
Jul 26, 2005·Infection and Immunity·Sven HammerschmidtManfred Rohde
Dec 26, 2006·Journal of Bacteriology·Magee Allegrucci, Karin Sauer
Sep 24, 1999·Thorax·J R Catterall
Aug 1, 1986·The Journal of Clinical Investigation·D M AmbrosinoG R Siber
Sep 26, 2013·BMC Infectious Diseases·Susanna RicciGianni Pozzi
Jun 13, 2009·PLoS Pathogens·Daniel M WeinbergerMarc Lipsitch
Aug 20, 2014·Infectious Diseases and Therapy·Haley J MorrillKerry L LaPlante
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·L A BurmanJ Henrichsen
Jan 1, 1982·Scandinavian Journal of Infectious Diseases·F B RoseC J Camp
Dec 29, 2013·Diagnostic Microbiology and Infectious Disease·Megan StaplesHelen V Smith
Jul 3, 2013·The Medical Clinics of North America·Samuel Y Ash, John V L Sheffield
Jun 9, 1998·Annals of the New York Academy of Sciences·K Prellner, O Kalm
Feb 13, 2013·Infectious Disease Clinics of North America·Daniel M Musher
Aug 1, 1992·Journal of Pediatric Surgery·D M AmbrosinoR C Shamberger
Dec 20, 2011·Analytical Biochemistry·Verônica M R GogolaViviane M Gonçalves
Jan 1, 1993·International Journal of Pediatric Otorhinolaryngology·M SvinhufvudK Prellner
Sep 17, 2005·Immunobiology·Estella A KoppelTeunis B H Geijtenbeek
Apr 23, 2004·Expert Opinion on Investigational Drugs·P H Cottagnoud, M G Täuber
Jan 1, 1988·Scandinavian Journal of Infectious Diseases. Supplementum·K Lehtomäki
May 13, 2015·Metallomics : Integrated Biometal Science·Edgar Augusto Ortiz-BenitezJosé de Jesús Olivares-Trejo
Mar 1, 2012·Virulence·Mathieu CoureuilXavier Nassif
Jul 17, 2010·FEMS Microbiology Letters·Hee Kuk ParkWonyong Kim
Dec 12, 2012·Journal of Molecular Microbiology and Biotechnology·Angelika RothRegine Hakenbeck
Jun 2, 2011·The Journal of Antimicrobial Chemotherapy·Dora RoloJosefina Liñares
Dec 5, 2013·World Journal of Clinical Cases·Ridvan AlimehmetiMentor Petrela
Sep 19, 2017·Pediatric Pulmonology·Kim M HareKeith Grimwood
Oct 13, 2017·Expert Opinion on Biological Therapy·Nicola Principi, Susanna Esposito
May 20, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G S Giebink
Apr 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E Bouza, P Muñoz
Oct 2, 2013·Infection and Immunity·Yuan LiMarc Lipsitch
Sep 29, 2006·The Pediatric Infectious Disease Journal·Jessica M BuckRuth Lynfield
Mar 15, 2008·Nature Reviews. Microbiology·Aras KadiogluPeter W Andrew
Jun 1, 1988·European Journal of Epidemiology·V RichardJ Klastersky
Aug 26, 2016·Beilstein Journal of Organic Chemistry·Markus W WeishauptPeter H Seeberger
Feb 24, 2017·Beilstein Journal of Organic Chemistry·Peter H SeebergerSubramanian Govindan
Aug 26, 1999·The Pediatric Infectious Disease Journal·P J TorzilloI Riley
Feb 13, 2001·Journal of Paediatrics and Child Health·C C GrantR Scragg
Mar 1, 1986·Journal of Clinical Pathology·L E Smart
Jul 3, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadja NoskeSven Hammerschmidt
Sep 1, 1990·Journal of General Internal Medicine·F M LaForce
Jan 25, 2017·The Cochrane Database of Systematic Reviews·Julia Ae WaltersRichard Wood-Baker
Jan 1, 1991·Acta Oto-laryngologica·M SvinhufvudC Schalén
May 15, 1993·Postgraduate Medicine·D Wisinger
Nov 4, 2000·The Medical Journal of Australia·P J Torzillo, M Gratten
Feb 20, 1995·The Medical Journal of Australia·P J TorzilloJ Erlich

Related Concepts

polysaccharide C-substance (Streptococcus)
Antigens, Bacterial
Bacterial Vaccines
Cell Wall
Clinical Trials
Otitis Media
Pneumococcal Infections
Streptococcal Pneumonia
Polysaccharides, Bacterial
Streptococcus pneumoniae

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