PMID: 1201270Nov 1, 1975Paper

Some observations on the possible nutritional significance of vitamin B12-and folate-binding proteins in milk. Absorption of [58Co]cyanocobalamin by suckling piglets

The British Journal of Nutrition
J E FordP J Taylor

Abstract

1. A study was made of absorption of [58Co]cyanocobalamin in suckling piglets. Cyanocobalamin given at birth and at 7 d of age was efficiently absorbed from the intestine and retained within the body, mostly in the liver. A 10 mug test dose was absorbed no less efficiently than 2-5 mug, despite the virtual absence of intrinsic factor in the gut. In piglets given a 10 mug test dose at different ages between 2-5 and 56 d, there was a marked decrease in the efficiency of retention between about 7 and 21 d of age. 2. Vitamin B12-binding capacity in the gastric muscosa increased with age, from 40 ng at birth to about 2000 ng at 14 d and 7000 ng at 35 d. This binder-protein was largely endogenous, whereas much of the unsaturated binder-protein in intestinal mucosa was apparently derived from milk. 3. The chyme in the stomach and small intestine contained unsaturated binder-protein, partly endogenous and partly deriving from milk, which prevented uptake of added [G-3H]-cyanocobalamin into the 'solids' phase of the intestinal contents. The intestinal chyme contained large numbers (log10 7-0--9-1/ml) of bacteria, some of which were isolated and shown to take up cyanocobalamin or folic acid or both. 4. The finings are discussed in relati...Continue Reading

References

May 29, 1971·Lancet·J Winberg, G Wessner
Feb 9, 1974·British Medical Journal·A Ifekwunigwe, D B Jelliffe
Aug 7, 1971·British Medical Journal·C L Bullen, A T Willis
Feb 1, 1970·The American Journal of Clinical Nutrition·F A Klipstein, S D Lipton
May 1, 1972·The British Journal of Nutrition·J E FordK J Scott
Nov 1, 1970·The American Journal of Clinical Nutrition·H Haenel
May 1, 1968·The British Journal of Nutrition·D L Williams, G H Spray
Sep 1, 1968·The British Journal of Nutrition·M E CoatesG F Harrison
Jun 1, 1966·The American Journal of Clinical Nutrition·J Ghitis
Jan 1, 1954·The British Journal of Nutrition·M E GREGORY
Mar 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·V HERBERT
Jan 1, 1959·The Journal of Endocrinology·R HALLIDAY
Jan 1, 1963·The American Journal of Physiology·A BOASS, T H WILSON
Apr 1, 1965·The American Journal of Clinical Nutrition·Y MATOTHC SROKA
Sep 1, 1947·The British Journal of Nutrition·R BRAUDE, M E COATES

❮ Previous
Next ❯

Citations

Nov 1, 1989·The British Journal of Nutrition·J S KopinskiW L Bryden
Aug 17, 2010·Journal of Animal Science·J J MatteC L Girard
Nov 1, 1980·Journal of the Science of Food and Agriculture·A G LowA G Low
Apr 1, 2019·Journal of Dairy Science·Sergey N FedosovChristian W Heegaard
Aug 11, 2006·European Journal of Clinical Nutrition·A L MørkbakE Nexø
Aug 21, 2002·Journal of Pediatric Gastroenterology and Nutrition·Yuriko Adkins, Bo Lönnerdal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.