PMID: 87Dec 15, 1975

Some physicochemical properties of hemoglobin-manitoba (alpha2 102Ser replaced by Arg (G9) beta2)

Biochimica Et Biophysica Acta
R N WrightstoneT H Huisman

Abstract

Hb-Manitoba was discovered in 1970 [1] in a Canadian family of British origin. Recently we observed the same variant in a second family, and found that the oxy-derivative of Hb-Manitoba is slightly unstable at 65 degrees C, dissociates less readily at alkaline pH than does Hb-A, and forms asymmetric hybrids with other hemoglobins which are readily detectable by electrophoresis.

References

Nov 1, 1971·The Journal of Clinical Investigation·M M KeelingT H Huisman
Nov 1, 1965·Analytical Chemistry·W A Schroeder, B Robberson
Apr 1, 1966·Biochemistry·D R BabinB Robberson
Mar 1, 1964·Biochemistry·A G KIRSHNER, C TANFORD

Related Concepts

Arginine hydrochloride
Electrophoresis, Starch Gel
Abnormal Hemoglobins
Hydrogen-Ion Concentration
Oxyhemoglobin
Serine
Variation (Genetics)

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