Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice.

BMC Microbiology
A PetersenTine Rask Licht

Abstract

Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet. The mice fed with diets containing fructo-oligosaccharide (FOS) or xylo-oligosaccharide (XOS) had significantly higher (P < 0.01 and P < 0.05) numbers of S. Typhimurium SL1344 in liver, spleen and mesenteric lymph nodes when compared to the mice fed with the cornstarch-based control diet. Significantly increased amounts (P < 0.01) of Salmonel...Continue Reading

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Citations

Aug 10, 2010·The British Journal of Nutrition·Marloes A A SchepensIngeborg M J Bovee-Oudenhoven
Jan 17, 2012·Current Opinion in Biotechnology·Dimitris Charalampopoulos, Robert A Rastall
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Methods Mentioned

BETA
flow cytometry
ELISA
FCS

Software Mentioned

Ascent
FCS Express
SAS JMP

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