Some recent developments regarding arthropathy and inhibitors in haemophilia

Haemophilia : the Official Journal of the World Federation of Hemophilia
E C Rodriguez-Merchan

Abstract

In this paper, the most recent developments on arthropathy and inhibitors in haemophilia are reviewed. Firstly, early long-term prophylaxis is strongly recommended in children with severe haemophilia. Secondly, in joint bleeds not responding to substitution of factor VIII to normal factor VIII levels angiographic embolization might be considered as a promising therapeutic option. Thirdly, recent data indicate disruption of normal development for adolescents with inhibitors. Fourthly, some case reports indicate the benefit of secondary prophylaxis with recombinant factor VIIa (rFVIIa) or factor eight inhibitor bypassing activity (FEIBA) in patients with severe haemophilia A and inhibitors. Finally, surgical procedures in haemophilia patients with factor inhibitors can be accomplished safely and effectively with FEIBA and/or rFVIIa, although the risk of complications is higher than in haemophilia patients without inhibitors.

References

Sep 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanF Hernández-Navarro

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Citations

Mar 27, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-Merchan, V Jimenez-Yuste
Jan 15, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanV Jimenez-Yuste
Jul 21, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S RangarajanJ Wilde
Jun 9, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·J W Hay, Z Y Zhou
Dec 2, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A BoadasA Ruiz-Sáez
Sep 10, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·E BerntorpG Young
Sep 21, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanA Caffarini
Dec 30, 2015·European Journal of Haematology·María Eva Mingot-CastellanoCarmen Sedano-Balbas

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