PMID: 241807Sep 1, 1975Paper

Some relations between dissolution rates and physical parameters of a drug in aqueous micellar solutions of a non-ionic surfactant

The Journal of Pharmacy and Pharmacology
J H Collett, J A Rees


Dissolution rates of salicylic acid from a constant surface area into a series of aqueous micellar polysorbate 20 solutions at pH 1-0 to 4-0 have been measured using two different methods; a stirred beaker and a rotating disc technique. The micellar molecular weight of polysorbate 20 has been obtained from light scattering and differential refractometry data and used with other independently determined physical data to calculate diffusion coefficients of the diffusing species. Linear multiple regression analysis was used to assess the dependence of drug dissolution rate on the diffusion coefficient and the viscosity of the dissolution medium.


Dec 1, 1974·The Journal of Pharmacy and Pharmacology·J A Rees, J H Collett
Sep 1, 1972·The Journal of Pharmacy and Pharmacology·J H CollettN A Dickinson
May 1, 1968·Journal of Pharmaceutical Sciences·M GibaldiN D Weiner
Feb 1, 1965·Journal of Pharmaceutical Sciences·D E WURSTER, P W TAYLOR


Aug 1, 1976·Journal of Pharmaceutical Sciences·F W Goodhart, M L Eichman

Related Concepts

Pharmaceutical Preparations
Hydrogen-Ion Concentration
Regression Analysis
Salicylic Acids

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