PMID: 9534094Apr 16, 1998Paper

Some similarities and differences between verapamil and the dihydropyridines

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
T F Antonios, G A MacGregor

Abstract

GROUPS OF CALCIUM CHANNEL BLOCKERS: The calcium channel blockers comprise a heterogeneous group of drugs. From both pharmacological and clinical points of view, they can be divided into three groups: the dihydropyridines, the phenylalkylamines and the benzothiazepines. REASONS FOR DIFFERENCES: There are important clinical and functional differences between the three groups. This may be explained by the fact that these families bind at different sites to the calcium channel. In this review, the major differences between the three groups are discussed, with an emphasis on verapamil.

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