Some studies on the release of histamine from mast cells stimulated with polylysine

British Journal of Pharmacology
M EnnisP M Weston

Abstract

1 Polylysine is an extremely potent releaser of histamine from rat peritoneal mast cells. Isolated mesenteric mast cells of the rat also respond to the secretagogue but guinea-pig mesenteric cells are unreactive. 2 The release does not require the presence of extracellular calcium ions but shows some dependence on internal stores of the cation. 3 The effect of polylysine is blocked by extremes of temperature and by metabolic inhibitors. 4 The release is very rapid and is virtually complete within 10 s of adding the inducer. 5 The release is unaffected by the anti-allergic drug, doxantrazole, but is inhibited by theophylline and disodium cromoglycate. The latter compounds are effective in both the presence and absence of added calcium. This result is discussed in terms of the postulated effect of the drugs on calcium transport.

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Citations

Sep 19, 2002·Phytotherapy Research : PTR·Tae-Yong ShinHyung-Min Kim
Dec 1, 1986·Inflammation·J G Elferink, M Deierkauf
Apr 1, 1984·Agents and Actions·P T Peachell, F L Pearce
Jul 1, 1993·Agents and Actions·A SantanaG de Nucci
Apr 1, 1997·Archives of Pharmacal Research·H M KimE J Lee
Sep 8, 2000·Archives of Pharmacal Research·T Y Shin, D K Kim
Jul 7, 2001·Archives of Pharmacal Research·T Y ShinE J Lee
Sep 5, 1980·European Journal of Pharmacology·M Ennis, F L Pearce
Jul 11, 1985·European Journal of Pharmacology·R Sagi-EisenbergR Shelly
May 12, 1994·European Journal of Pharmacology·C M GiraldeloE Antunes
Jun 7, 2005·Toxicology and Applied Pharmacology·Tae-Yong ShinHyung-Min Kim
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·C F P TeixeiraY Cury
Oct 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M YiH M Kim
Mar 23, 2000·International Journal of Immunopharmacology·H Y ShinM H Kim
Sep 8, 1998·International Journal of Immunopharmacology·H KimJ Kim
Sep 21, 2000·Journal of Ethnopharmacology·T Y ShinH M Kim
Feb 19, 2002·Journal of Ethnopharmacology·Jin Mu YiHyung Min Kim
Sep 10, 2003·Journal of Ethnopharmacology·Seung-Heon HongHyung-Min Kim
May 15, 1998·Journal of Ethnopharmacology·H M KimT Y Shin
Jan 5, 2000·Journal of Ethnopharmacology·H M KimT Y Shin
Nov 6, 2001·Immunopharmacology and Immunotoxicology·T Y ShinH M Kim
Oct 12, 2002·Immunopharmacology and Immunotoxicology·Tae-Yong ShinSang-Hyun Kim
Apr 5, 2003·Immunopharmacology and Immunotoxicology·Tae-Yong Shin, Jae-Kwan Lee
Jun 24, 2004·Immunopharmacology and Immunotoxicology·Sang-Yong KimTae-Yong Shin
Dec 1, 1990·British Journal of Pharmacology·E AntunesG de Nucci
May 5, 1999·Pharmacology & Toxicology·H M KimK Y Jung
May 4, 2000·The American Journal of Chinese Medicine·H M KimT Y Shin

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