PMID: 9420619Jan 8, 1998Paper

Some thoughts on the response to antigens that are effector T-helper independent ('thymus independence')

Scandinavian Journal of Immunology
Melvin Cohn

Abstract

The Self-Non-Self discrimination is germline-selected for defence mechanisms ('innate immune systems') whereas it is somatically learned for immune systems ('adaptive immune systems'). It is proposed that immune system evolved from defence mechanisms by adding large recognitive repertoires that, by aggregating with antigens, were able to trigger the already existent effector functions of defence mechanisms. Thus today there are two pathways to triggering each class of effector function (macrophage opsonization, complement lysis or natural killer/-natural cytotoxic cell activity). The antigen-antibody complex and the T-cell antigen-receptor interaction trigger the immune pathway: the receptors of the defence mechanism trigger the 'alternate' or 'innate' pathway. The evolutionary selection pressure on defence mechanisms was to increase the size of the recognitive repertoire, which in turn, necessitated the emergence of a somatically learned Self-Non-Self discrimination. By contrast with defence mechanisms that are triggered effector T-helper (eTh) independently by polymers (Signal[3]), immune systems can be activated by monomers, a pathway that requires associative recognition of monomer and the reading of two Signals, Signal[1] ...Continue Reading

References

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H M DintzisB Vogelstein
May 1, 1992·Scandinavian Journal of Immunology·Y LinM Cohn
Feb 1, 1991·Scandinavian Journal of Immunology·R E Langman, M Cohn
Jan 1, 1995·Annual Review of Immunology·J J MondC M Snapper

❮ Previous
Next ❯

Citations

Mar 5, 2003·Trends in Immunology·Melvin Cohn
Jun 21, 2005·Scandinavian Journal of Immunology·M Cohn
Aug 22, 2006·Scandinavian Journal of Immunology·J Cunliffe
Jan 12, 2008·Parasite Immunology·I G Colditz
Jul 27, 2006·Scandinavian Journal of Immunology·M Cohn
Oct 17, 2002·Cellular Immunology·Rodney E Langman, Melvin Cohn
Mar 29, 2012·Cultural Anthropology : Journal of the Society for Cultural Anthropology·A David Napier
Sep 24, 2005·Scandinavian Journal of Immunology·M Cohn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.