Something Old and Something New: An Update on the Amazing Repertoire of Bacteriocins Produced by Streptococcus salivarius

Probiotics and Antimicrobial Proteins
Philip A WescombeJohn R Tagg

Abstract

Streptococcus salivarius has an exclusive and intimate association with humans. We are its sole natural host, and its contribution to the relationship appears overwhelmingly benevolent. Beautifully adapted to its preferred habitat, the human tongue, it only rarely ventures far from this location in the healthy host and indeed appears ill-equipped to become invasive due to a scarcity of virulence attributes. We consider that its strategically advantageous lingual location and numerical predominance allow S. salivarius to carry out a population surveillance and modulation role within the oral microbiota. Some strains are armed with complex arrays of targeted antibiotic weaponry, much of which belongs to the lantibiotic class of bacteriocins and a key to their ability to assemble and utilize this armament is their possession of transmissible multi-bacteriocin-encoding megaplasmid DNA. This review traces the origins of research into S. salivarius bacteriocins and bacteriocin-like inhibitory substances, showcases some of the inhibitory activities that we currently have knowledge of, and speculates about potential directions for ongoing investigation and probiotic application of this previously under-rated human commensal.

References

Nov 1, 1979·Journal of Medical Microbiology·D W JohnsonL W Wannamaker
Sep 12, 1991·The New England Journal of Medicine·A L Bisno
Apr 1, 1985·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·W L Hynes, J R Tagg
Nov 1, 1973·Infection and Immunity·W F Liljemark, R J Gibbons
Mar 1, 1970·Journal of Dental Research·J CarlssonS Wikner
Sep 1, 1981·Canadian Journal of Microbiology·J R Tagg, C Russell
Sep 5, 1998·International Journal of Food Microbiology·I IvanovaP Boyaval
Jan 12, 2001·Oral Microbiology and Immunology·C H Sissons, S Yakub
Jan 5, 2002·Applied and Environmental Microbiology·Christine F FavierAntoon D L Akkermans
May 16, 2002·Periodontology 2000·Walter J Loesche, Christopher Kazor
Nov 27, 2002·Applied and Environmental Microbiology·Marina D GeorgalakiEffie Tsakalidou
May 7, 2003·Applied and Environmental Microbiology·Philip A Wescombe, John R Tagg
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·Seamus J BuckleyBrendan F O'Connor
Dec 23, 2004·Paediatric Drugs·Diana Lennon
Oct 29, 2005·The Lancet Infectious Diseases·Jonathan R CarapetisMartin Weber
Jan 1, 1992·Applied and Environmental Microbiology·C B LewusT J Montville
Apr 7, 2006·Applied and Environmental Microbiology·Jeremy P BurtonJohn R Tagg
Jul 28, 2006·Antonie van Leeuwenhoek·Philip A WescombeJohn R Tagg
Nov 7, 2006·Journal of Bacteriology·Christine DelormePierre Renault
Aug 3, 2007·The New England Journal of Medicine·Jonathan R Carapetis
Jan 16, 2008·Advances in Experimental Medicine and Biology·James B Dale
Jun 19, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D A PowerJ R Tagg
Jan 28, 2009·BMC Biology·Cynthia J BishopBrian G Spratt
Jun 10, 2009·Antimicrobial Agents and Chemotherapy·Sikder M AsaduzzamanKenji Sonomoto

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Citations

Sep 3, 2009·Future Microbiology·Philip A WescombeJohn R Tagg
Dec 13, 2012·Future Microbiology·Philip A WescombeJohn R Tagg
Feb 1, 2011·Expert Opinion on Drug Discovery·Mohammed M Al-Mahrous, Mathew Upton
Sep 24, 2016·Genome Announcements·Fang Jia
Dec 5, 2017·Current Oral Health Reports·Robert P Allaker, Abish S Stephen
Nov 26, 2010·Applied and Environmental Microbiology·Annechien PlatGert N Moll
Apr 23, 2017·Applied and Environmental Microbiology·Narimane DahmaneSophie Payot
Nov 1, 2011·Journal of Bacteriology·Nicholas C K HengJohn R Tagg
Aug 3, 2010·The Protein Journal·Abdelmajid ZouhirJeannette Ben Hamida
Jul 8, 2016·The Open Dentistry Journal·Nagendrababu VenkateshbabuNath Sonia
Nov 11, 2011·Journal of Immunotoxicology·Zahoor Ul HassanMnaza Noreen
Nov 5, 2016·Probiotics and Antimicrobial Proteins·Mohamed ZommitiMounir Ferchichi
Apr 4, 2021·International Journal of Molecular Sciences·Hideo YonezawaShigeru Kamiya
Apr 16, 2021·Probiotics and Antimicrobial Proteins·Ghazi KhalfallahRudolf Lütticken
May 13, 2021·International Journal of Clinical Pediatric Dentistry·Srihari Nirguna ChandrasekharHenna P Salim
Sep 8, 2018·Microbiology Spectrum·Debra E BessenBernard W Beall
Dec 30, 2021·Vestnik otorinolaringologii·E L SavlevichA N Gerasimov

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