Something special about CO-dependent CO2 fixation

The FEBS Journal
Joana C XavierWilliam F Martin

Abstract

Carbon dioxide enters metabolism via six known CO2 fixation pathways, of which only one is linear, exergonic in the direction of CO2 -assimilation, and present in both bacterial and archaeal anaerobes - the Wood-Ljungdahl (WL) or reductive acetyl-CoA pathway. Carbon monoxide (CO) plays a central role in the WL pathway as an energy rich intermediate. Here, we scan the major biochemical reaction databases for reactions involving CO and CO2 . We identified 415 reactions corresponding to enzyme commission (EC) numbers involving CO2 , which are non-randomly distributed across different biochemical pathways. Their taxonomic distribution, reversibility under physiological conditions, cofactors and prosthetic groups are summarized. In contrast to CO2 , only 15 reaction classes involving CO were detected. Closer inspection reveals that CO interfaces with metabolism and the carbon cycle at only two enzymes: anaerobic carbon monoxide dehydrogenase (CODH), a Ni- and Fe-containing enzyme that generates CO for CO2 fixation in the WL pathway, and aerobic CODH, a Mo- and Cu-containing enzyme that oxidizes environmental CO as an electron source. The CO-dependent reaction of the WL pathway involves carbonyl insertion into a methyl carbon-nickel ...Continue Reading

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Citations

Oct 24, 2019·Interface Focus·Martina PreinerWilliam F Martin
Nov 19, 2019·Frontiers in Bioengineering and Biotechnology·Sylwia Stegenta-DąbrowskaAndrzej Białowiec
Feb 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yao ZhangGerhard J Herndl
Jun 4, 2020·International Journal of Molecular Sciences·Habibu AliyuAnke Neumann
Jul 14, 2020·Frontiers in Microbiology·William F Martin
Dec 13, 2019·Journal of the American Chemical Society·Anne-Christine SchulzOliver Lenz
Mar 28, 2021·Communications Biology·Joana C XavierWilliam F Martin
Oct 23, 2020·Chemical Reviews·Christopher P HopperBinghe Wang

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Software Mentioned

UpSetR
Powerneedle
BRENDA
RAxML
ClustalW
RPy2
BLAST
iPath

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