Sometimes intermediates. Do the job!

Chemistry & Biology
Rolf Hilgenfeld, Ksenia Pumpor

Abstract

The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives .

References

Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·D A MatthewsS T Worland
Oct 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Haitao YangZihe Rao
Jul 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chung-Yi WuChi-Huey Wong

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Citations

Nov 7, 2006·Current Opinion in Structural Biology·Jeroen R MestersRolf Hilgenfeld
Jun 19, 2008·Chemistry & Biology·Koen H G VerschuerenRolf Hilgenfeld

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