Somnogenic activity of immune response modifiers

Trends in Pharmacological Sciences
J M Krueger

Abstract

Sleepiness is a presenting symptom in nearly all infectious diseases. James Krueger describes how microbial products, such as muramyl peptides, lipid A and double-stranded RNA, as well as endogenous products elicited by these substances, such as interleukin 1, modulate sleep. The altered sleep during infection seems to result from an exaggerated activation of physiological sleep mechanisms, since normal sleep is controlled by a wide range of substances including many of these immune response modifiers.

References

Jan 1, 1987·Annals of the New York Academy of Sciences·J M Krueger, M L Karnovsky
May 1, 1989·Physiology & Behavior·M OppJ M Krueger
Sep 1, 1989·Infection and Immunity·L JohannsenJ M Krueger
Jun 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H MoldofskyR Gorczynski
Oct 23, 1987·Science·M D Lumpkin
Feb 1, 1989·Infection and Immunity·A B CadyJ M Krueger
Oct 31, 1988·Biochemical and Biophysical Research Communications·K YamamotoO Hayaishi
Oct 1, 1988·The International Journal of Neuroscience·F A LueH Moldofsky
Dec 1, 1987·Immunological Reviews·W L FarrarM Vinocour
Jul 1, 1988·Infection and Immunity·L A Toth, J M Krueger
May 1, 1986·Psychosomatic Medicine·H MoldofskyR M Gorczynski
Dec 27, 1974·Science·W A Carter, E De Clercq
Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M KruegerM L Karnovsky

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Citations

Jan 1, 1992·European Archives of Psychiatry and Clinical Neuroscience·S GudewillF Holsboer
Nov 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·V W PentreathF Doua
Aug 1, 1991·Trends in Pharmacological Sciences·J MeldolesiT Pozzan
Jan 1, 1992·Trends in Pharmacological Sciences·S KentR Dantzer
Apr 1, 1991·Trends in Neurosciences·G Nisticò, G De Sarro
Feb 1, 1994·International Journal of Immunopharmacology·L JohannsenJ M Krueger
Aug 1, 1995·International Journal of Immunopharmacology·H Moldofsky
Jan 12, 1996·Neuroscience Letters·H NishinaY Taketani
Jul 23, 1997·European Journal of Pharmacology·F NavaA P Caputi
Mar 17, 1999·European Journal of Pharmacology·F Nava, A P Caputi
Sep 26, 2003·Journal of Psychosomatic Research·Giorgio GrossiKristina Orth-Gomér
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·I FeinbergK Anderson
Aug 23, 2001·Neuroscience Letters·F Nava, G Carta
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L N HeissW E Goldman
Sep 1, 1995·Journal of Sleep Research·H MoldofskyR M Gorczynski
Sep 23, 2014·Acta Neuropsychiatrica·Salih Saygin EkerEmre Sarandol
Jan 1, 1995·Advances in Neuroimmunology·J M KruegerS Novitsky
Nov 21, 2007·Sleep Medicine·Fotis KapsimalisMeir Kryger
Oct 7, 2015·Autism Research : Official Journal of the International Society for Autism Research·Stefano GabrieleAntonio M Persico
Mar 15, 2006·Current Opinion in Anaesthesiology·Thomas Uhlig, Konrad W Kallus
Oct 8, 1999·Chronobiology International·E Haus, M H Smolensky
Apr 19, 2003·Holistic Nursing Practice·Felissa R Lashley
Mar 24, 2021·Cell Communication and Signaling : CCS·Zhen ZhangXuefei Tian
Aug 1, 1993·Infection and Immunity·L N HeissW E Goldman

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