PMID: 2105668Jan 11, 1990Paper

Somnogenic, pyrogenic, and hematologic effects of bacterial peptidoglycan

The American Journal of Physiology
L JohannsenJ M Krueger

Abstract

Bacterial infections and certain muramyl peptides elicit a variety of pathophysiological effects including increases in body temperature and slow-wave sleep. Bacterial cell wall peptidoglycan is composed of muramyl peptides. To investigate the ability of isolated bacterial cell walls to enhance slow-wave sleep, rabbits were injected intravenously with cell walls isolated from Staphylococcus aureus or with soluble peptidoglycan prepared from Neisseria gonorrhoeae. These injections increased slow-wave sleep, electroencephalographic delta-wave amplitudes, and body temperature, reduced rapid-eye-movement sleep, and induced neutrophilia and lymphopenia. The somnogenic and pyrogenic effects of S. aureus cell walls developed within 1 h and persisted throughout the recording period. Injections of N. gonorrhoeae peptidoglycan induced similar effects but of larger magnitude and shorter duration. We conclude that peptidoglycan is a bacterial component that mediates the increased sleep observed during infectious disease.

Citations

Sep 11, 2010·Journal of Applied Physiology·James M KruegerMark R Zielinski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Related Papers

The American Journal of Physiology
D Davenne, J M Krueger
The American Journal of Physiology
J M KruegerD Davenne
The Journal of Rheumatology. Supplement
J M Krueger, L Johannsen
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
L Johannsen
© 2021 Meta ULC. All rights reserved