Abstract
Erectile dysfunction (ED) is a serious medical condition in which current treatments are ineffective in prostatectomy and diabetic patients, due to injury to the cavernous nerve (CN), which causes irreversible remodeling of the penis (decreased smooth muscle and increased collagen), through a largely undefined mechanism. We propose that sonic hedgehog (SHH) and neural innervation, are indispensable regulators of collagen in the penis, with decreased SHH protein being an integral component of the fibrotic response to loss of innervation. We examined collagen abundance and morphology in control (Peyronie's), prostatectomy and diabetic patients, and in rat models of penile development, CN injury, SHH inhibition and under regenerative conditions, utilizing self-assembling peptide amphiphile (PA) nanofiber hydrogels for SHH delivery. Collagen abundance increased in penis of ED patients. In rats, collagen increased with CN injury in a defined time frame independent of injury severity. An inverse relationship between SHH and collagen abundance was identified; SHH inhibition increased and SHH treatment decreased penile collagen. SHH signaling in the pelvic ganglia (PG)/CN is important to maintain CN integrity and when inhibited, downst...Continue Reading
References
Jan 1, 1966·Acta Anatomica·T S Leeson, C R Leeson
Jun 1, 1996·Clinical Biochemistry·G K Reddy, C S Enwemeka
Sep 28, 2000·Journal of Biomechanics·A GefenD Elad
Oct 12, 2000·The Journal of Urology·A C PinheiroF J Sampaio
Jan 23, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Raymond P Boot-Handford, Danny S Tuckwell
May 16, 2003·Biology of Reproduction·Carol A PodlasekKevin T McVary
Aug 5, 2004·BJU International·Wan-Li HuBing-Chun Tian
Apr 12, 2005·The Journal of Urology·Fabrizio IaconoVincenzo Mirone
Dec 28, 2005·Current Pharmaceutical Design·C A PodlasekK T McVary
Jan 18, 2006·The Journal of Sexual Medicine·Michael MulleradJohn P Mulhall
Sep 22, 2006·Biology of Reproduction·Carol A PodlasekKevin T McVary
Jun 22, 2007·Experimental Neurology·Matthew R Nangle, Janet R Keast
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nduka M AmankulorEric C Holland
Oct 3, 2009·The Journal of Sexual Medicine·Julio Eduardo FerrerAna Milena Herrera
Oct 28, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiaming WenYang Xia
Jun 15, 2010·Nature Materials·Shuming ZhangSamuel I Stupp
Jul 28, 2010·Journal of the National Cancer Institute·Vasileia-Ismini AlexakiAlain Mauviel
Sep 3, 2010·The Journal of Sexual Medicine·Christopher W BondCarol A Podlasek
Oct 26, 2010·Biomaterials·Nicholas L AngeloniCarol A Podlasek
Feb 4, 2012·Journal of the American Society of Nephrology : JASN·Hong DingYouhua Liu
Feb 23, 2012·Arthritis and Rheumatism·Angelika HornJörg H W Distler
Sep 22, 2012·The Journal of Sexual Medicine·Nicholas AngeloniCarol A Podlasek
Oct 2, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alfredo Lozano BolañosMoisés Selman
Oct 4, 2012·The American Journal of Pathology·Natacha CignaArnaud A Mailleux
Feb 2, 2013·American Journal of Respiratory Cell and Molecular Biology·Li LiuJohn S Munger
Aug 24, 2013·PloS One·Nicholas L AngeloniCarol A Podlasek
Oct 15, 2013·Biomaterials·Eric J BernsSamuel I Stupp
Dec 7, 2013·PloS One·Siu Wai TsangZhaoxiang Bian
May 2, 2014·TheScientificWorldJournal·Dogan AtilganUnal Erkorkmaz
Aug 21, 2014·American Journal of Respiratory Cell and Molecular Biology·Biao HuSem H Phan
Sep 4, 2014·Acta Cirúrgica Brasileira·Jorge Luiz Medeiros JúniorBianca Martins Gregório
Citations
Aug 19, 2016·Advanced Drug Delivery Reviews·Handan AcarMatthew Tirrell
Sep 10, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Shawn ChoeCarol A Podlasek
Jan 10, 2017·The Journal of Sexual Medicine·Alice Y Wang, Carol A Podlasek
Aug 19, 2017·International Journal of Molecular Sciences·Jeffrey D Campbell, Arthur L Burnett
Jan 3, 2018·Biopolymers·Ria J BetushBradley L Nilsson
Sep 7, 2018·Chemical Society Reviews·Kohei SatoSamuel I Stupp
Nov 18, 2017·Interface Focus·Kingshuk BasuArindam Banerjee
Oct 28, 2019·Bioscience Trends·Natakarn NimsanorAungkura Supokawej
Jan 20, 2020·Andrology·Fan DingXiaojun Wu
Apr 16, 2018·Macromolecular Rapid Communications·Qiuxia FuBin Ding
Aug 11, 2020·The World Journal of Men's Health·Min Chul ChoSoo Woong Kim
Nov 9, 2017·Advanced Healthcare Materials·Kelly M HainlineJoel H Collier
Jan 17, 2020·Cell Proliferation·Wende YangHongbo Wei
Oct 11, 2017·Bioengineering & Translational Medicine·Yi LiHonggang Cui
Jul 17, 2019·Current Medicinal Chemistry·Fei PengFeng Qiu
Dec 31, 2020·International Journal of Nanomedicine·Luis Alberto Castillo-DíazAndrea Isabel Enríquez-Rodríguez
Mar 13, 2021·The Journal of Sexual Medicine·Sarah MartinCarol A Podlasek
May 1, 2021·International Journal of Molecular Sciences·Justyna SawickaSylwia Rodziewicz-Motowidło
Jul 28, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Sarah MartinCarol A Podlasek