Sonic Hedgehog functions by localizing the region of proliferation in early developing feather buds

Developmental Biology
Iain W McKinnellKetan Patel

Abstract

Feathers are formed following a series of reciprocal signals between the epithelium and the mesenchyme. Initially, the formation of a dense dermis leads to the induction of a placode in the overlying ectoderm. The ectoderm subsequently signals back to the dermis to promote cell division. Sonic Hedgehog (Shh) is a secreted protein expressed in the ectoderm that has previously been implicated in mitogenic and morphogenetic processes throughout feather bud development. We therefore interfered with Shh signaling during early feather bud development and observed a dramatic change in feather form and prominence. Surprisingly, outgrowth did occur and was manifest as irregular, fused, and ectopic feather domains at both molecular and morphological levels. Experiments with Di-I and BrdU indicated that this effect was at least in part caused by the dispersal of previously aggregated proliferating dermal cells. We propose that Shh maintains bud development by localizing the dermal feather progenitors.

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Citations

Feb 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Frederic MichonDanielle Dhouailly
Jul 23, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juntang LinChristoph Redies
Mar 30, 2016·Development, Growth & Differentiation·Kentaro Ishida, Toshiyuki Mitsui
May 11, 2007·Differentiation; Research in Biological Diversity·Yoshiyuki ShiroyanagiLaurence S Baskin
Jul 20, 2005·Differentiation; Research in Biological Diversity·Jae-Young KimHan-Sung Jung
Jun 6, 2014·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Tatsuya HirasawaShigeru Kuratani
Jan 24, 2007·Developmental Biology·Guodong LiuPeter C W Kim
May 19, 2006·Developmental Biology·Jason DolesWade Bushman
May 18, 2016·Molecular Biology and Evolution·Chih-Kuan ChenWen-Hsiung Li
Feb 2, 2017·BMC Genomics·Chih-Kuan ChenWen-Hsiung Li
Aug 25, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Angèle Tingaud-SequeiraPatrick J Babin
Mar 27, 2021·EvoDevo·Tyler A SquareCraig T Miller

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