Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing.

Nature Neuroscience
Liseth M Parra, Yimin Zou

Abstract

Pathfinding axons change responses to guidance cues at intermediate targets. During midline crossing, spinal cord commissural axons acquire responsiveness to class 3 Semaphorins and Slits, which regulate their floor plate exit and restrict their post-crossing trajectory into a longitudinal pathway. We found that Sonic Hedgehog (Shh) could activate the repulsive response of pre-crossing axons to Semaphorins. Blocking Shh function with a monoclonal antibody to Shh, 5E1, in 'open-book' explants or by expressing a dominant-negative form of Patched-1, Ptch1(Delta loop2), or a Smoothened (Smo) shRNA construct in commissural neurons resulted in severe guidance defects, including stalling and knotting inside the floor plate, recrossing, randomized anterior-posterior projection and overshooting after crossing, reminiscent of Neuropilin-2 mutant embryos. Enhancing protein kinase A activity in pre-crossing axons diminished Shh-induced Semaphorin repulsion and caused profound midline stalling and overshooting/wandering of post-crossing axons. Therefore, a morphogen, Shh, can act as a switch of axon guidance responses.

References

Dec 13, 2003·Science·Anna I LyuksyutovaYimin Zou
Feb 21, 2004·Science·Jonathan R Terman, Alex L Kolodkin
Mar 5, 2005·Nature Neuroscience·Dimitris BourikasEsther T Stoeckli
Oct 13, 2006·Annual Review of Cell and Developmental Biology·Barry J Dickson, Giorgio F Gilestro
Jan 15, 2008·Developmental Biology·Wei GuanMaureen L Condic
Mar 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alex M WolfYimin Zou
Jun 23, 2009·Current Opinion in Neurobiology·R Jeroen Pasterkamp, Roman J Giger

❮ Previous
Next ❯

Citations

Mar 15, 2013·Trends in Neurosciences·Irina Dudanova, Rüdiger Klein
Mar 10, 2011·Nature Reviews. Neuroscience·Takuro TojimaHiroyuki Kamiguchi
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yesser H Belgacem, Laura N Borodinsky
Jul 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xavier NicolNicholas C Spitzer
Jun 11, 2010·Cold Spring Harbor Perspectives in Biology·Barry J Dickson, Yimin Zou
Nov 5, 2011·Genes & Development·R Tyler HillmanMatthew P Scott
May 6, 2011·Neural Development·Pascal JosetMatthias Gesemann
Nov 13, 2012·Neural Development·Melanie PhilippEsther T Stoeckli
Sep 14, 2011·PLoS Genetics·Leticia Sanchez-AlvarezAntonio Colavita
Nov 19, 2013·Journal of Hepatology·Nataliya RazumilavaGregory J Gores
May 4, 2011·Cellular and Molecular Life Sciences : CMLS·Homaira Nawabi, Valérie Castellani
Aug 21, 2010·Current Opinion in Neurobiology·Alain Chédotal
Jul 27, 2010·Trends in Cell Biology·Alwin A H A DerijckR Jeroen Pasterkamp
Jul 24, 2012·The Journal of Comparative Neurology·Masaaki ToriiPat Levitt
Sep 24, 2015·Annual Review of Cell and Developmental Biology·Catarina CatelaJeremy S Dasen
Mar 10, 2015·Current Opinion in Genetics & Development·Stryder M Meadows, Ondine Cleaver
Jul 27, 2015·Experimental Neurology·Jose A MartinezDouglas W Zochodne
Mar 18, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Alexandra Neuhaus-Follini, Greg J Bashaw
Jan 27, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Edward Martinez, Tracy S Tran
Nov 5, 2013·Current Opinion in Neurobiology·Patricia T Yam, Frédéric Charron
Mar 27, 2012·Communicative & Integrative Biology·Ronald S PetraliaPamela J Yao
Jul 6, 2014·Seminars in Cell & Developmental Biology·Isabel Guerrero, Thomas B Kornberg
Oct 1, 2010·Developmental Biology·Carl M GayJesús Torres-Vázquez
Jan 7, 2015·Archives of Toxicology·Yanfei JiaJingwu Xie
Sep 10, 2016·ELife·Irving E WangPeter W Reddien
Jun 10, 2016·Developmental Neurobiology·Fernando Vonhoff, Haig Keshishian
Jan 5, 2017·Cell Reports·Melissa Hernandez-FlemingGreg J Bashaw
Dec 10, 2016·Molecular Biology of the Cell·Pamela J YaoMark P Mattson
Feb 6, 2018·Journal of Developmental Biology·Tanushree Pandit, Stacey K Ogden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.