Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth.

Molecular and Cellular Biochemistry
Lunshan XuHongjuan Cui

Abstract

Accumulated evidence suggests a major role for the activation of the Sonic Hedgehog (SHH) signaling pathway in the development of neural crest stem cells that give rise to the sympathetic nervous system. We therefore investigated the involvement of SHH signaling in the pathogenesis of neuroblastoma (NB), a common childhood malignant tumor of the sympathetic nervous system. Inhibition of SHH signaling by cyclopamine induced apoptosis and blocked proliferation in all major types of NB cells, and abrogated the tumorigenicity of NB cells. Our study has revealed a molecular mechanism for the persistent activation of the SHH pathway which promotes the development of NB, and suggests a new approach for the treatment of this childhood malignant tumor.

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Citations

Aug 26, 2020·Cell Biochemistry and Function·Xiaoying LiJuntang Lin
Dec 21, 2017·Scientific Reports·Aubrey L MillerKarina J Yoon
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dae-Hee LeeSang Cheul Oh
Sep 5, 2014·Cell Death & Disease·L Planells-FerrerJ X Comella
Aug 8, 2018·International Journal of Molecular Sciences·Xian Zeng, Dianwen Ju
May 2, 2019·Frontiers in Molecular Neuroscience·Marianna SzemesKarim Malik
May 8, 2014·BioResearch Open Access·Jianhua WanHongjuan Cui
Jul 5, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Aranzazu VillasanteGordana Vunjak-Novakovic

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