Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development

Brain Plasticity
Odessa R Yabut, Samuel J Pleasure

Abstract

The mammalian neocortex is composed of a diverse population of neuronal and glial cells that are crucial for cognition and consciousness. Orchestration of molecular events that lead to the production of distinct cell lineages is now a major research focus. Recent studies in mammalian animal models reveal that Sonic Hedgehog (Shh) signaling plays crucial roles in this process. In this review, we will evaluate these studies and provide insights on how Shh signaling specifically influence cortical development, beyond its established roles in telencephalic patterning, by specifically focusing on its impact on cells derived from the cortical radial glial (RG) cells. We will also assess how these findings further advance our knowledge of neurological diseases and discuss potential roles of targeting Shh signaling in therapies.

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Citations

Mar 16, 2019·Scientific Reports·Katherine L O'ShaughnessyMary E Gilbert
Feb 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Johanna HietamäkiTaneli Raivio
May 30, 2020·Cellular and Molecular Neurobiology·Juliana BaranovaRicardo G Correa
Jan 14, 2021·Cells·David de Agustín-DuránCristina Gil-Sanz
Apr 4, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Mohammed ShqiratToshiyuki Ohtsuka
Jun 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mengying YangMargaret S Ho
Aug 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hui WangMichael P Matise

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Methods Mentioned

BETA
nuclear translocation

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