Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma.

Actas dermo-sifiliográficas
O SanmartínS Puig

Abstract

Sonidegib is an antagonist of the transmembrane protein Smoothened in the Hedgehog signaling pathway. It is indicated for the treatment of locally advanced basal cell carcinoma (BCC) that is not amenable to curative surgery or radiotherapy. Sonidegib's efficacy and safety were demonstrated in the phase 2 BOLT trial, where 61% (95% CI, 48-72%) of patients with locally advanced BCC treated with sonidegib 200 mg achieved an objective response to treatment with a mean time to response of 4 months. The median duration of response was 26.1 months and the median progression-free survival was 22.1 months. The most common adverse events were muscle spasms (54.4%), hair loss (49.4%), and loss of taste (44.3%); most events were grade 1 or 2. In this review, we summarize the main findings on the efficacy, safety, and tolerability of sonidegib and discuss the management of locally advanced BCC with this drug.

References

Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Jan 22, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M NorvalJ C van der Leun
Jan 19, 2012·The British Journal of Dermatology·A LomasF Bath-Hextall
Jun 8, 2012·The New England Journal of Medicine·Aleksandar SekulicAxel Hauschild
Nov 30, 2012·The Journal of Investigative Dermatology·Sophie C FlohilTamar Nijsten
Feb 27, 2013·Indian Dermatology Online Journal·Lyubomir A DourmishevIvan Botev
Jun 4, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Charlene LamElizabeth M Billingsley
Feb 14, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jordi RodonAlain C Mita
Aug 13, 2015·BioMed Research International·Julia TichyMichel Mittelbronn
Feb 8, 2016·Actas dermo-sifiliográficas·A Tejera-VaquerizoI García-Doval
Nov 23, 2017·International Journal of Molecular Sciences·Cristina PellegriniMaria Concetta Fargnoli
Dec 24, 2017·Bosnian Journal of Basic Medical Sciences·Ana Marija SkodaLjiljana Serman
Jul 10, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ketty PerisUNKNOWN European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Rese
Nov 21, 2019·The Australasian Journal of Dermatology·Matthew Gibson, Dedee Frances Murrell
Jan 29, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·R DummerR J J Grob
Mar 14, 2020·Archives of Dermatological Research·Shweta Shukla, Amor Khachemoune
May 10, 2020·Dermatology and Therapy·Dennis NiebelJennifer Landsberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.