Sonochemical synthesis of cellulose/hydroxyapatite nanocomposites and their application in protein adsorption

Scientific Reports
Lian-Hua FuMing-Guo Ma

Abstract

Hydroxyapatite (HA) is the main mineral constituent in the hard tissue of vertebrate, which is recognized as an important biomedical material owing to its excellent bioactivity and biocompatibility. Herein, we report a facile and green sonochemical route for the rapid synthesis of cellulose/HA nanocomposites in NaOH/urea aqueous solution. The in vitro behavior of the cellulose/HA nanocomposites was studied to evaluate the biological response of the nanocomposites following immersion in simulated body fluid for various periods (maximum of 28 days). The HA crystals formed on the surface of the nanocomposites were carbonate-containing apatite, which is similar to the naturally occurring calcium phosphate materials. The HA nanosheets (assembly of nanorods) were mineralized on the surface of the nanocomposites, and maximum mass of the nanocomposites was reached 1.82 times of initial mass after 28 days of soaking. Moreover, the as-prepared cellulose/HA nanocomposites have good cytocompatibility, and show a relatively high protein adsorption ability using hemoglobin as a model protein. These results indicate that the as-prepared cellulose/HA nanocomposites are promising for applications in various biomedical fields such as tissue engi...Continue Reading

References

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Citations

Dec 12, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Danushika C ManatungaK M Nalin de Silva
Sep 18, 2020·Advances in Colloid and Interface Science·Shixiang LiuHailin Cong
Oct 19, 2020·International Journal of Biological Macromolecules·Dariela NúñezPatricio Oyarzún
Oct 23, 2019·ACS Applied Materials & Interfaces·Zheng ChengHongli Zhu
Nov 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanting LyuHiroshi Uyama

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BETA
X-ray
scanning electron microscopy

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PeakFitv
Image J
SeaSolve

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