Sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70

Japanese Journal of Cancer Research : Gann
N YumitaR Nishigaki

Abstract

The sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70, was evaluated in mice bearing colon 26. In order to find the optimum timing for the ultrasonic exposure after the administration of ATX-70, the ATX-70 concentrations in the plasma, skin, and tumor were measured and analyzed. Antitumor effect was estimated by measuring the tumor size. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of ATX-70 was increased, while use of ATX-70 alone had no significant effect. At an ATX-70 dose of 2.5 mg/kg or higher, the average tumor size decreased to smaller than a half by three days after the ultrasonic exposure. This was smaller than a third of the size of the untreated tumors on the same day. From these results, it is concluded that ATX-70 significantly sensitizes tumors to ultrasound, demonstrating a synergistic antitumor effect.

References

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Citations

Mar 6, 2010·Cancer Chemotherapy and Pharmacology·Nagahiko YumitaShin-Ichiro Umemura
Apr 19, 1996·Cancer Letters·K UmemuraS Umemura
Dec 5, 2003·Ultrasound in Medicine & Biology·Moustafa M MohamedNivan M Fikry
May 7, 1998·Cancer Letters·S UmemuraR Nishigaki
Oct 10, 2002·Ultrasonics Sonochemistry·Nagahiko YumitaShin-ichiro Umemura
Mar 20, 2004·Ultrasonics Sonochemistry·Tinghe YuTimothy J Mason
Jan 15, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·David CostleyJohn F Callan
Nov 4, 2000·Expert Opinion on Investigational Drugs·D R Richardson, D B Lovejoy
Oct 22, 2008·Ultrasonics·Jhony El MaaloufJean-Louis Mestas
May 23, 2008·Ultrasonics·Katarzyna Milowska, Teresa Gabryelak
Mar 21, 2006·Thrombosis Research·Azita Soltani, Charles Soliday
Dec 14, 2005·Ultrasound in Medicine & Biology·Katarzyna Milowska, Teresa Gabryelak
Sep 27, 2001·Japanese Journal of Cancer Research : Gann·K SasakiS I Umemura
Jun 9, 1998·Japanese Journal of Cancer Research : Gann·K SasakiS Umemura
Apr 1, 2017·Therapeutic Delivery·Henry Hirschberg, Steen J Madsen
Sep 26, 2007·Anti-cancer Drugs·Nagahiko YumitaShin-Ichiro Umemura
Feb 24, 2006·Radiation Research·Manabu Kinoshita, Kullervo Hynynen
Oct 20, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Maxime LafondShin-Ichiro Umemura
May 26, 2020·Current Drug Delivery·Weiqiu JinDaocheng Wu
Mar 21, 2007·Bioconjugate Chemistry·Nami SugitaShin-ichiro Umemura

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