Sonodynamically induced antitumor effect of pheophorbide a

Cancer Letters
K UmemuraS Umemura

Abstract

The sonodynamically induced antitumor effect of pheophorbide a (Ph-a) was investigated. Both in vitro and in vivo effects on sarcoma 180 were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced cell damage in air-saturated suspension was enhanced by twice with 80 microM Ph-a. This enhancement was significantly inhibited by histidine, which may suggest it was mediated by ultrasonically induced oxidation. For mice, 5 mg/kg Ph-a was administered before the insonation, and ultrasound stopped the tumor growth at an intensity with which ultrasound alone showed only a slight antitumor effect.

References

Aug 1, 1979·Journal of Clinical Ultrasound : JCU·F W Kremkau
Mar 1, 1990·Japanese Journal of Cancer Research : Gann·N YumitaS Umemura
Sep 1, 1990·Japanese Journal of Cancer Research : Gann·S UmemuraK Umemura
Mar 1, 1989·Japanese Journal of Cancer Research : Gann·N YumitaS Umemura
May 1, 1993·Japanese Journal of Cancer Research : Gann·S UmemuraR Nishigaki
Mar 1, 1996·Japanese Journal of Cancer Research : Gann·N YumitaR Nishigaki

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Citations

Mar 6, 2010·Cancer Chemotherapy and Pharmacology·Nagahiko YumitaShin-Ichiro Umemura
Sep 21, 2013·Journal of Photochemistry and Photobiology. B, Biology·Haiping WangXiaobing Wang
Dec 5, 2003·Ultrasound in Medicine & Biology·Moustafa M MohamedNivan M Fikry
Mar 20, 2004·Ultrasonics Sonochemistry·Tinghe YuTimothy J Mason
Sep 26, 2007·Anti-cancer Drugs·Nagahiko YumitaShin-Ichiro Umemura
Mar 20, 2013·BioMed Research International·Faina NakonechnyMarina Nisnevitch
Dec 1, 2002·Journal of Medical Ultrasonics·Loreto B FerilPeter Riesz
Oct 18, 2012·Ultrasonics Sonochemistry·Bei ChenWeimin Zhang
Dec 27, 2015·Pharmacology & Therapeutics·Xin PangAlbert Wingnang Leung
Oct 22, 2008·Ultrasonics·Jhony El MaaloufJean-Louis Mestas
Mar 21, 2006·Thrombosis Research·Azita Soltani, Charles Soliday
Oct 15, 2013·Biopharmaceutics & Drug Disposition·Caifeng LiXiaobing Wang
Sep 18, 2015·Chemotherapy Research and Practice·Matthew Trendowski
Mar 3, 2015·Ultrasound in Medicine & Biology·Andrew K W Wood, Chandra M Sehgal
Mar 10, 2010·Ultrasound in Medicine & Biology·Xiao Bing WangXiu Juan Li
Jul 4, 2019·Angewandte Chemie·Xiahui LinHuanghao Yang
Dec 22, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Quanhong LiuYan Wang
Jul 4, 2020·Photodiagnosis and Photodynamic Therapy·Mehran AkselMehmet Dincer Bilgin
Dec 14, 2005·Ultrasound in Medicine & Biology·Katarzyna Milowska, Teresa Gabryelak

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