Sonography monitoring of thyroid morphology and function in patients with metastatic renal cell carcinoma treated with targeted drugs.

Annals of Palliative Medicine
Chen LiuAiping Zhou

Abstract

The incidence rate of renal cell carcinoma (RCC) has gradually increased worldwide over the past decade. Targeted therapy is the primary method for treating metastatic renal cell carcinoma (mRCC), and the development of thyroid dysfunction is one of the most common adverse reactions of this treatment. Therefore, this study aimed to assess the value of sonography in monitoring the morphology and functions of the thyroid in metastatic renal cell carcinoma patients treated with targeted drugs. In total, 37 patients from September 2016 to April 2019 with clinically confirmed mRCC that were treated with targeted drugs (19 with sunitinib and 18 with sorafenib) were enrolled in this study. The enrolled patients were divided into the hypothyroidism group and the non-hypothyroidism groups according to the changes in the serum concentration of the thyroid-stimulating hormone (TSH) during the treatment period. The serum concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and TSH were measured by the Roche method before and after treatment. Simultaneously, the major axis, transverse diameter, and anteroposterior diameter of the bilateral lobes and isthmus of the thyroid gland were measured by ultrasound, and every thyroid ...Continue Reading

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