PMID: 9641388Jun 26, 1998Paper

Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy: incidence and time course

Journal of Clinical Ultrasound : JCU
N A AvilaR Eastman

Abstract

We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly. We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. Group I (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. Group II (10 patients) was treated with ursodiol while receiving octreotide therapy. Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72% (13/18) and calculi in 39% (7/18). Ursodiol reversed the gallbladder abnormalities in 7 of 10 patients. A majority of patients receiving octreotide develop gallbladder abnormalities. Ursodiol appears to reverse the abnormalities in most cases.

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Citations

Nov 13, 2015·Expert Review of Gastroenterology & Hepatology·P PortincasaD Q-H Wang
Jul 18, 2015·Expert Opinion on Drug Safety·Ludovica F S GrassoAnnamaria Colao
Nov 28, 2006·Best Practice & Research. Clinical Gastroenterology·Niels G Venneman, Karel J van Erpecum
Apr 18, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu
Jul 29, 2016·Korean journal of family medicine·Piero PortincasaIgnazio Grattagliano
Mar 7, 2008·Current Treatment Options in Gastroenterology·Chad I Williams, Eldon A Shaffer
Oct 15, 2008·Journal of Endocrinological Investigation·R AttanasioE Ghigo
May 9, 2002·Drug Metabolism Reviews·Slobodan Rendic
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Agostino Di CiaulaPiero Portincasa

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