Sorafenib for Advanced Hepatocellular Carcinoma: A Real-Life Experience

Digestive Diseases
Larisse LongoMário Reis Álvares-da-Silva

Abstract

Sorafenib (SOR) has proved to be effective in patients with advanced hepatocellular carcinoma (HCC), since overall survival was higher in phase III clinical trials; however, disease progression can occur. The study aimed to describe real-life experience in advanced HCC treatment with SOR at a university hospital in Brazil and to estimate the number of patients with indication of second-line therapy. This is a retrospective study that included cases of HCC with prescription of SOR based on real-life practice between 2011 and 2016. Demographic, clinical, and laboratory data were collected. From 572 patients with HCC, SOR was prescribed in 103 cases. From them, 62.1% were classified as Child-Pugh (CP)-A, 54.4% as Barcelona Clinic Liver Cancer (BCLC)-C, and 74 (71.8%) started treatment. Overall survival was 25.5 (95% CI 17.0-34.1) months and 1-year survival was greater in patients who received SOR than in non-treated (88.7 vs. 44.4%, p < 0.001). There was no difference in survival between BCLC-B and C (p = 0.405), as well as CP-A and B (p = 0.919). In 21.6% of the patients, a second-line therapy with regorafenib was indicated. In this real-life study, SOR significantly increased the survival rate by 1 year in patients with advanced...Continue Reading

Citations

Sep 22, 2020·World Journal of Gastroenterology : WJG·Michela Anna PolidoroMatteo Donadon
Jul 10, 2019·Cancers·Zuzanna Tracz-Gaszewska, Pawel Dobrzyn
Nov 17, 2019·Cancers·Enya LiDa-Liang Ou
Jul 25, 2019·Cancer Research·Lee Jin LimCaroline G Lee
Jan 24, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahmoud A YounisHideyoshi Harashima
Nov 18, 2019·Advanced Drug Delivery Reviews·Xiaozhong HuangHanry Yu
Oct 12, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Young-Sun LeeSang Y Hwang

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