Sorafenib in combination with ionizing radiation has a greater anti-tumour activity in a breast cancer model

Anti-cancer Drugs
Mitra HeraviThierry M Muanza

Abstract

High expression of vascular endothelial growth factor (VEGF) in patients with breast cancer has been associated with a poor prognosis, indicating that VEGF could be linked to the efficacy of chemotherapy and radiotherapy. It has also been suggested that radiation resistance is partly due to tumour cell production of angiogenic cytokines, particularly VEGF receptor (VEGFR). This evidence indicates that inhibition of VEGFR might enhance the radiation response. Sorafenib tosylate (Bay 54-9085) is an oral, small-molecule multikinase inhibitor of several targets including RAF/MEK/ERK MAP kinase signalling, VEGFR-2, VEGFR-3 and platelet-derived growth factor receptor-beta. Sorafenib has shown clinical efficacy in treating solid tumours such as renal cell and hepatocellular carcinomas. However, strategies are yet to be identified to prolong and maximize the anticancer effect of this multikinase inhibitor. The objective of this study was to determine whether a combination of Sorafenib and radiation will enhance the treatment response in vitro and in vivo. Radio-modulating effect of Sorafenib was assessed by performing clonogenic assays. In addition, cell cycle analyses as well as annexin-V apoptosis assays were performed 24 and 48 h af...Continue Reading

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Citations

May 30, 2013·Cancer Biotherapy & Radiopharmaceuticals·Julia Alejandra PezukLuiz Gonzaga Tone
Aug 22, 2013·Breast Cancer Research and Treatment·Claudia FumarolaMara A Bonelli
Jan 20, 2016·Cytotherapy·Osama Muhammad MariaThierry Muanza
Jun 25, 2013·Cancer Biology & Therapy·María Sol BrassescoLuiz Gonzaga Tone
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Mar 26, 2016·Oncotarget·Nikolaus MöckelmannMalte Kriegs

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