Sorafenib increases 18-FDG colic uptake: demonstration in patients with differentiated thyroid cancer.

EJNMMI Research
Renaud CiappucciniStéphane Bardet

Abstract

To assess 18-fluorodeoxyglucose (FDG) bowel uptake in patients with differentiated thyroid cancer (DTC) treated with sorafenib. Visual (5-point scale) and high maximum standard uptake value (SUVmax) semi-quantitative analyses were conducted in 63 positron emission tomography (PET) studies performed in patients on sorafenib (group 1, n = 20), in a control group (group 2, n = 28) and in patients on sunitinib or vandetanib (group 3, n = 15).Moderate or high and diffuse bowel uptake (grade 4 or 5) was observed in 90% of the PET scans of group 1 versus none in group 2. Only 20% of PET scans in group 3 were scored grade 4. SUVmax values were significantly higher for all colic segments in group 1 than in group 2 (P < 0.0001) or 3 (P < 0.0004). This uptake pattern appeared rapidly (one month) and disappeared after sorafenib withdrawal. FDG uptake is increased in the colon of DTC patients treated by sorafenib.

References

Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Sep 6, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Eric GontierJean-Louis Alberini
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Natascha A J B PetersLukas J A Stalpers
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vandana Gupta-AbramsonMarcia S Brose
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Aug 30, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y LoriotF Goldwasser
Aug 5, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George R BlumenscheinMartin Reck
Nov 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardBernd J Krause
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elaine T LamManisha H Shah
Apr 16, 2010·The Journal of Clinical Endocrinology and Metabolism·Maria E CabanillasNaifa L Busaidy
Mar 10, 2011·Thyroid : Official Journal of the American Thyroid Association·Marie-Elisabeth ToubertGuilhem Bousquet
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Jae Hoon LeeHye Jin Choi

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Citations

Feb 26, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Iain J NixonMichael R Tuttle

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