Sorafenib induces delayed-onset cutaneous hypersensitivity: a case series

Allergy, Asthma & Immunology Research
Kyoung Hee SohnHye Ryun Kang

Abstract

Sorafenib is an oral multikinase inhibitor with clinical activity against hepatocellular carcinoma (HCC) and renal cell carcinoma. Administration of sorafenib carries a variety of adverse cutaneous reactions. Common adverse effects induced by sorafenib include hand-foot skin reactions, facial erythema, splinter subungual hemorrhage, and alopecia. Although erythema multiforme (EM) related to sorafenib has been reported, delayed-type cutaneous hypersensitivity reactions are rare in patients treated with sorafenib and there has been no case of Stevens-Johnson syndrome (SJS) reported so far. We recently experienced 3 cases of delayed-type cutaneous hypersensitivity related to administration of sorafenib. The first case was a 47-year female had targetoid erythematous rashes on her arms 12 days after starting sorafenib for HCC. The rashes spread from the arms to the trunk rapidly except for the hands and feet, and erosive lesions developed in the oral mucosa and lips. She was diagnosed as SJS. The second case was an 81-year-old male had maculopapular eruptions with multiple targetoid lesions on the trunk, arms, and legs 10 days after starting sorafenib for his HCC. There was no evidence of mucosal involvement. He was diagnosed with E...Continue Reading

References

Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N YawalkarW J Pichler
Apr 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark J RatainPeter J O'Dwyer
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Jan 24, 2007·Journal of the American Academy of Dermatology·Jennifer L MacGregorWilliam H Sherman
Jul 23, 2008·Archives of Dermatology·Julien AutierCaroline Robert
Jun 12, 2009·Cutaneous and Ocular Toxicology·Cemal BilaçPeyker Temiz
Jun 25, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M KodairaK Hatake
Feb 9, 2011·Pharmacogenetics and Genomics·Hye-Ryun KangUNKNOWN Adverse Drug Reaction Research Group in Korea
Sep 20, 2011·European Journal of Dermatology : EJD·Mio NambaMakoto Kawashima
Jul 12, 2012·Japanese Journal of Clinical Oncology·Masaomi IkedaMasatsugu Iwamura

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Citations

Jun 18, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dong Kyun KimSung Wook Lee
Mar 28, 2017·Emergency Medicine Journal : EMJ·Hon-Pheng Tam, Wei-Jing Lee
May 7, 2021·Proceedings·Aaminah Faheem AzharJordan Jamerson

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