Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor

Molecular Cancer Therapeutics
Hung HuynhKhee Chee Soo

Abstract

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Current therapeutic options include surgery and targeted molecular approaches such as imatinib and sunitinib. Our aim was to establish patient-derived GIST xenografts for the use of screening new drugs and improving current treatment regimens used in GIST. In this present study, we investigate the antitumor activity of sorafenib against patient-derived GIST xenografts. Murine xenograft models were given two oral doses of sorafenib daily for 30 days and growth of established tumor xenografts was monitored at least twice weekly by vernier caliper measurements. Western blotting was then used to determine changes in proteins in these xenografts before and after sorafenib therapy. Apoptotic and cell proliferation were analyzed by immunohistochemisty. Our data found that oral administration of sorafenib to mice, bearing patient-derived GIST xenografts, resulted in dose-dependent inhibition of tumor growth. Sorafenib-induced growth inhibition was associated with decreased cell proliferation, increased apoptosis, and reduction in tumor angiogenesis. Western blot analysis revealed that sorafenib inhibited C-Raf, phospho-extracellula...Continue Reading

References

Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Sep 30, 2003·The British Journal of Surgery·E M ConnollyJ V Reynolds
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessMichael C Heinrich
Sep 29, 2004·Journal of Clinical Pathology·S CarvalhoF C Schmitt
Jan 19, 2005·The American Journal of Gastroenterology·Thomas TranHashem B El-Serag
Sep 2, 2005·Cancer·Sanne M van der Zwan, Ronald P DeMatteo
Apr 21, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria Debiec-RychterUNKNOWN Australasian GastroIntestinal Trials Group
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hung HuynhEvelyn Tran
Jul 22, 2006·Annals of Surgery·Jason S Gold, Ronald P Dematteo
Sep 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
Oct 4, 2006·Nature Reviews. Drug Discovery·Scott WilhelmSusan Kelley
Oct 5, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H Joensuu
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tianhua GuoCristina R Antonescu
Nov 21, 2007·Journal of Clinical Pharmacy and Therapeutics·P ReddyC Charbonneau
Feb 1, 2008·Nature Clinical Practice. Oncology·Stefan SleijferJaap Verweij
Jul 24, 2008·Journal of Gastroenterology·Shigeharu MiwaToshiro Sugiyama

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Citations

Nov 30, 2011·International Journal of Colorectal Disease·Alexander W BehamB Michael Ghadimi
Jun 11, 2011·Clinical and Experimental Medicine·Tian-bao WangWen-guang Dong
Aug 19, 2011·Journal of Clinical Immunology·Oliver CrespoWilliam H Robinson
May 4, 2012·Archives of Pharmacal Research·Do-Hee Kim, Taebo Sim
Feb 2, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G RoubaudA Italiano
Oct 27, 2010·World Journal of Gastroenterology : WJG·Tian-Bao WangWen-Guang Dong
Feb 11, 2014·Journal of Translational Medicine·Jason K SicklickAndrew M Lowy
Jul 8, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jingchuan ZhangQun Wang
Jun 23, 2015·Expert Opinion on Investigational Drugs·Hani J AlturkmaniAndrew K Godwin
Nov 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M MontemurroD Pink
Mar 2, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yue-Lei ChenXiaoyan Ding
Oct 19, 2011·Molecular Carcinogenesis·Rit VatsyayanSharad S Singhal
Jul 15, 2015·Future Oncology·Gennaro Gadaleta-CaldarolaMario Brandi
Mar 10, 2011·Expert Opinion on Therapeutic Targets·Margherita NanniniMaria A Pantaleo
May 26, 2016·Mitochondrion·Marcos Roberto de Oliveira
Jun 23, 2020·Oxidative Medicine and Cellular Longevity·Ahmed NabilMitsuhiro Ebara
Jul 22, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Won Kyu KimHoguen Kim
Nov 30, 2014·Cancer Research·Nathalie Javidi-SharifiJeffrey W Tyner
Apr 21, 2021·Cancer Metastasis Reviews·Bayan Al-SharePhilip A Philip
Mar 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G RoubaudA Italiano

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