PMID: 25778319Mar 18, 2015Paper

Sorafenib inhibits liver cancer growth by decreasing mTOR, AKT, and PI3K expression

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
Chi-zhi ZhangLi-qin Chao

Abstract

The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/mTOR signaling pathway and to further define its mechanism for treating hepatocellular carcinoma (HCC). Human SMMC-7721 hepatic carcinoma cells were treated with or without 4 μmoL/L sorafenib. SMMC- 7721 cells were harvested at various time points (0-48 hrs) and assessed for changes in PI3K, mTOR, and AKT protein and mRNA levels. Human SMMC-7721 hepatic tumor cells exposed to sorafenib had decreased expression of PI3K/mTOR/AKT. Sorafenib appears to inhibit hepatic tumor growth by downregulating PI3k/Akt/mTOR signaling pathway.

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