Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Keisuke KohgaNorio Hayashi

Abstract

The ectodomain of major histocompatibility complex class I-related chain A (MICA) is shed from tumor cells, and may be an important means of evading antitumor immunity. This study investigated the roles of a disintegrin and metalloproteinase 9 (ADAM9) in the shedding of MICA in human hepatocellular carcinoma (HCC). Small interfering RNA-mediated knockdown (KD) of ADAM9 resulted in up-regulation of membrane-bound MICA expression on the HepG2 and PLC/PRF/5 cellular surfaces and down-regulation of soluble MICA levels in their culture supernatant. ADAM9 was cleaved at a site between Gln347 and Val348 of MICA in vitro. We constructed a plasmid of the MICA gene with mutation or deletion of the ADAM9 cleavage site to examine the detailed mechanism of MICA shedding by ADAM9 protease. The results suggested that MICA might be cleaved at the intracellular ADAM9-recognized cleavage site and was further cleaved at the extracellular ADAM9-independent cleavage site in HCC cells, resulting in the production of soluble MICA. Immunohistochemical analysis revealed that ADAM9 was overexpressed in human HCC compared to normal liver tissues. The cytolytic activity of natural killer (NK) cells against ADAM9KD-HCC cells was higher than that against co...Continue Reading

References

May 23, 1998·Annual Review of Immunology·L L Lanier
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
May 12, 2000·Immunological Reviews·D G Doherty, C O'Farrelly
Feb 24, 2001·Gastroenterology·W Z MehalI N Crispe
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi SuemizuHidetoshi Inoko
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helmut R SalihAlexander Steinle
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Masahisa JinushiNorio Hayashi
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guido Ferlazzo, Christian Münz
Oct 28, 2004·Gastroenterology·Giovanna FattovichFrancesco Donato
Oct 28, 2004·Gastroenterology·F Xavier BoschRamon Cléries
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Lizzia RaffaghelloVito Pistoia
Aug 12, 2005·International Journal of Cancer. Journal International Du Cancer·Stefan HoldenriederHelmut Rainer Salih
Dec 29, 2005·Journal of Clinical Immunology·Kouetsu Ogasawara, Lewis L Lanier
Aug 8, 2006·Gastroenterology·Kenichi TakayasuUNKNOWN Liver Cancer Study Group of Japan
Aug 18, 2006·Seminars in Cancer Biology·Jérôme D Coudert, Werner Held
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tomohide TatsumiNorio Hayashi
Mar 16, 2007·Cancer Science·Satsuki Mochizuki, Yasunori Okada
Apr 29, 2008·Biochimica Et Biophysica Acta·Philippe F DevauxMichael M Kozlov
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Aug 5, 2008·Cancer Research·Inja WaldhauerAlexander Steinle
Nov 29, 2008·Cancer Science·Shinji Tanaka, Shigeki Arii
Dec 5, 2008·The New England Journal of Medicine·Giancarlo Spinzi, Silvia Paggi
Feb 20, 2009·Journal of Gastroenterology·Melanie Thomas

❮ Previous
Next ❯

Citations

Feb 4, 2012·Cancer Immunology, Immunotherapy : CII·Keisuke KohgaTetsuo Takehara
Nov 29, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessandro CucchettiAntonio Daniele Pinna
Dec 18, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ming ShiKam M Hui
Apr 16, 2013·Experimental and Molecular Pathology·Soya S SamJoel A Lefferts
Jan 19, 2011·BMC Gastroenterology·Rodolfo SaccoCarlo Bartolozzi
Feb 13, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin WangSubrata Sen
Nov 14, 2013·Cancer Chemotherapy and Pharmacology·Hidenari NagaiYasukiyo Sumino
Nov 3, 2011·Clinical & Developmental Immunology·Francesco DituriSalvatore Antonaci
Feb 18, 2014·European Journal of Cell Biology·Nives MoroPaola Zigrino
Jul 6, 2014·Biological & Pharmaceutical Bulletin·Kenta YagiToshiaki Sendo
Jan 5, 2012·Cancer Immunology, Immunotherapy : CII·Leticia Huergo-ZapicoSegundo Gonzalez
Sep 17, 2015·Immunologic Research·Gordana KonjevićKatarina Mirjačić Martinović
Oct 21, 2015·Nature Reviews. Gastroenterology & Hepatology·Jesús PrietoBruno Sangro
Sep 20, 2011·European Journal of Immunology·Sonia Agüera-GonzálezMar Valés-Gómez
Feb 20, 2013·International Journal of Cancer. Journal International Du Cancer·Hiroshi AketaTetsuo Takehara
May 18, 2013·Scandinavian Journal of Immunology·G ChitadzeD Kabelitz
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Hinako TsunematsuTetsuo Takehara
Jun 6, 2012·Clinical & Developmental Immunology·Hidenari NagaiYasukiyo Sumino
Jun 16, 2015·Acta Pharmacologica Sinica·Cheng SunZhi-gang Tian
Aug 19, 2015·Immunological Reviews·Raphael Carapito, Seiamak Bahram
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Yu QiuQing-Guo Zhu
Jan 16, 2013·Clinical & Developmental Immunology·Magali TermeJulien Taieb
Jul 16, 2011·Journal of Hepatology·Hiroteru KamimuraYutaka Aoyagi
Jul 30, 2011·Journal of Hepatology·Mario U Mondelli
Jul 23, 2014·Oncoimmunology·Aroa Baragaño RanerosCarlos López-Larrea
Nov 17, 2012·Biochemical and Biophysical Research Communications·Eriko ShinozukaToshihiro Takizawa
Oct 2, 2014·Journal of Gastroenterology·Kaku Goto, Naoya Kato
Nov 18, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomohide Tatsumi, Tetsuo Takehara
Mar 22, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Yoshifumi Itoh
Feb 4, 2012·Journal of Proteomics·Mairead Anne MurphyDolores Josephine Cahill
Oct 22, 2017·Journal of Gastroenterology and Hepatology·Jun AraiNaoya Kato
Apr 19, 2018·HLA : Immune Response Genetics·N Kumar, S I Khakoo
Jan 13, 2018·Clinical & Translational Immunology·Caryn L ElsegoodGeorge Ct Yeoh
Jun 7, 2018·International Journal of Cancer. Journal International Du Cancer·Jun AraiNaoya Kato
Dec 18, 2018·Molecular Oncology·Victor O OriaOliver Schilling
Nov 24, 2018·Hepatology International·Lihui ZhuangSalim I Khakoo
Apr 20, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carina HageCarola H Ries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.