Sorbent augmented hemodialysis systems: are we there yet?

Journal of the American Society of Nephrology : JASN
James F Winchester, Claudio Ronco

Abstract

Recent publications have reintroduced the concept of using sorbent systems to augment the efficiency of the dialysis process, either by making stationary or compact wearable devices to regenerate dialysis fluid or to target larger molecules for removal by direct blood or plasma contact with sorbent particles. Many of the inherent problems associated with older sorbents have been overcome by designing sorbents with improved biocompatibility and potential for removing molecules beyond the limits of conventional dialysis membranes. One system is approved for use in acute renal failure in the United States, but other devices are not approved for use in humans and continue to be tested in animals and humans. A prototype wearable sorbent device under investigation is not yet able to meet acceptable small molecular weight solute removal, and the other sorbent devices that possess the ability to remove unconventional uremic toxins have not been studied sufficiently in dialysis patients to define their role as augmentation devices. That there is a renewal of interest in sorbents in augmentation of dialysis points to the dissatisfaction with current dialysis technology.

References

Aug 11, 2000·Kidney International. Supplement·A L Marinez de FranciscoC Tetta
Nov 30, 2000·Journal of the American Society of Nephrology : JASN·Richard A WardWalter Samtleben
Jun 20, 2002·Critical Care Medicine·Claudio RoncoCiro Tetta
Dec 20, 2002·The New England Journal of Medicine·Garabed EknoyanUNKNOWN Hemodialysis (HEMO) Study Group
Jan 21, 2004·Blood Purification·James F WinchesterNathan W Levin
Aug 4, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fredrik UhlinMartin Magnusson
Aug 26, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Francesco PiccolominiCarlo Donadio
Jan 26, 2007·Journal of the American Society of Nephrology : JASN·Timothy W MeyerThomas H Hostetter
Sep 28, 2007·The New England Journal of Medicine·Timothy W Meyer, Thomas H Hostetter
Apr 11, 2008·Contributions to Nephrology·Eric SchifferRaymond C Vanholder
Apr 19, 2008·Blood Purification·Juan Jesus CarreroPeter Stenvinkel
May 16, 2008·The New England Journal of Medicine·Björn ZetheliusJohan Arnlöv
Apr 21, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Victor GuraClaudio Ronco

❮ Previous
Next ❯

Citations

Oct 22, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Andrew Davenport
Jan 15, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badreldin H AliNicole Schupp
Feb 26, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wee-Keat CheahFei-Yee Yeoh
Nov 10, 2012·Circulation Research·Suree LekawanvijitHenry Krum
Dec 7, 2011·Hemodialysis International·Andrew Davenport

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Suguru YamamotoValentina Kon
Experimental Biology and Medicine
Badreldin H AliAbderrahim Nemmar
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Badreldin H AliGerald Blunden
Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology
Kent R Olson
© 2021 Meta ULC. All rights reserved