PMID: 2123806Sep 1, 1990Paper

Sorbinil does not prevent galactose-induced glomerular capillary basement membrane thickening in the rat

Diabetologia
A DasN L Zhang

Abstract

We investigated the role of the polyol pathway in the pathogenesis of glomerular basement membrane thickening in galactosaemic rats, an animal model that develops basement membrane lesions comparable to those of human diabetic subjects. Normotensive Wistar-Kyoto rats fed a 30% galactose diet for nine months developed significant glomerular basement membrane thickening by comparison with rats on a control test diet (p = 0.008). However, addition of an aldose reductase inhibitor, sorbinil (250 mg/kg diet), to the galactose diet did not prevent the increase in glomerular basement membrane thickness. Furthermore, by using a quantitative electron microscopic immunogold technique, we examined biochemical alterations in the composition of glomerular basement membranes in this animal model. The labelling density (comparable to relative concentration) of collagen type IV in thickened glomerular basement membranes of galactosaemic animals was significantly increased by comparison to those of control rats (p = 0.015). However, there was no significant difference in labelling densities of laminin and heparan sulfate proteoglycan core protein of these animals. Thus, our results indicate that an increase in glomerular basement membrane thick...Continue Reading

References

Aug 1, 1989·Diabetes·B S Daniels, T H Hostetter
May 1, 1989·The American Journal of Physiology·C BrugnaraD C Tosteson
Mar 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D S Grant, C P Leblond
Sep 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M BendayanF W Kan
Feb 1, 1988·Kidney International·J J CohenJ A Benson
Aug 1, 1988·The Journal of Clinical Investigation·E CaglieroM Lorenzi
Feb 1, 1987·Diabetes·T S Kern, R L Engerman
Apr 19, 1973·The New England Journal of Medicine·K H Gabbay
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A RatcliffeT E Hardingham
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R HassellG R Martin
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Y S KanwarM L Jakubowski
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·C Hasslacher, P Wahl
Jul 31, 1980·Biochemical and Biophysical Research Communications·M P CohenV Y Wu

❮ Previous
Next ❯

Citations

Jul 1, 1995·Diabetes/metabolism Reviews·R L Engerman, T S Kern
Jun 1, 1992·Diabetologia·R G Larkins, M E Dunlop
May 8, 1999·Journal of Diabetes and Its Complications·T S Kern, R L Engerman
Jan 1, 1995·European Journal of Pediatrics·G T Berry
Oct 1, 1993·Journal of Diabetes and Its Complications·A S Reddi, G N Jyothirmayi
May 15, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A KatoI Adachi
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Xiping XinSubrata Chakrabarti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.