Sorbinil suppresses glomerular prostaglandin production in the streptozotocin diabetic rat

Metabolism: Clinical and Experimental
P A Craven, F R DeRubertis

Abstract

Previous studies have suggested a link between hyperfiltration and enhanced polyol pathway activity in the streptozotocin diabetic rat. In the present study we examined the relationship between glomerular sorbitol content, a measure of polyol pathway activity and glomerular filtration rate (GFR), as a function of plasma glucose and time after induction of diabetes. GFR is increased by 1 to 2 weeks in the untreated streptozotocin diabetic rat but falls to values equal to or below control by 2 months. Treatment of diabetic rats with a low dose of insulin to achieve moderate hyperglycemia results in the maintenance of elevated GFR for 2 months. Glomerular sorbitol content in the 1- to 2-week diabetic rats was not significantly different from values in glomeruli from control rats at 1 to 2 weeks but was 11-fold higher than control by 2 months in the untreated diabetic rat. Treatment of diabetic rats with insulin to achieve moderate hyperglycemia resulted in values for glomerular sorbitol content that were not different from control. Thus, elevated GFR was not associated with elevated glomerular sorbitol content in the 1- to 2-week diabetic rat and was dissociated from elevated glomerular sorbitol content in the 2-month diabetic rat...Continue Reading

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Citations

Apr 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·D R Tomlinson
Jun 1, 1992·Diabetologia·R G Larkins, M E Dunlop
Jan 1, 1992·Pharmacology & Therapeutics·D R TomlinsonA L Carrington

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