Sorbitol and other polyols in lens, adipose tissue and urine in diabetes mellitus.

Clinica Chimica Acta; International Journal of Clinical Chemistry
D J Heaf, D J Galton

Abstract

Sugars and polyols (glucose, fructose, sorbitol, inositol and pentitols) have been measured in urine, adipose tissue and lens in groups of diabetic and non-diabetic patients. The daily excretions of glucose, sorbitol and inositol were raised in the diabetics. There was a linear relation between 24 hour urinary excretion of glucose and hexitols (r = +0.87, p less than 0.001). In lens of diabetics there was an increase in glucose concentration, but not of fructose, sorbitol or inositol. Compounds readily detected in adipose tissue were inositol and glucose; in addition an unidentified carbohydrate was detected in adipose tissue that related to the concentration of tissue glucose. These results are discussed in relation to the possibility that tissue accumulation of polyols could be responsible for the secondary complications of diabetes such as cataracts.

Citations

Jun 1, 1992·Diabetologia·R G Larkins, M E Dunlop
Feb 14, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·S L Johnson, M Mayersohn
Jul 10, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·R ShinoharaI Ishiguro
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S K SrivastavaB Das
Feb 1, 1981·Clinical Biochemistry·C HubinontW J Malaisse
Oct 9, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Junghyun KimJin Sook Kim
Oct 1, 1980·Acta Ophthalmologica·S D VarmaR D Richards

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