Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes
Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat
The sorbitol pathway: effect of streptozotocin induced diabetes and the feeding of a sucrose-rich diet on glucose, sorbitol and fructose in the retina, blood and liver of rats
The polyol pathway for glucose metabolism in tissues from normal, diabetic, and ketotic Chinese hamsters
Pathological changes in the central and peripheral nervous system of young long-term diabetics. II. The spinal cord and peripheral nerves
Variations in motor conduction velocity produced by acute changes of the metabolic state in diabetic patients
Diabetic neuropathy. An experimental study in alloxanised rats, with special reference to insulin therapy
Hemorheologic and hemostatic changes in long-standing insulin-dependent (type I) diabetic patients with peripheral and autonomic cardiovascular neuropathy
Role of red cell sorbitol as determinant of reduced erythrocyte filtrability in insulin-dependent diabetics
Improvement of endoneurial lipid abnormalities in experimental diabetic neuropathy by oxygen modification
Plasma fucose and sialic acid concentrations during oral glucose tolerance tests in normal and diabetic (mellitus) humans
The effect of continuous subcutaneous insulin infusion therapy on morphological and biochemical abnormalities of peripheral nerves in experimental diabetes
Ultrastructural observations on myelinated fibres in experimental diabetes: effect of the aldose reductase inhibitor ponalrestat given alone or in conjunction with insulin therapy
Aldose reductase mRNA expression and its activity are induced by glucose in fetal rat aortic smooth muscle (A10) cells
A new prostaglandin E1 analogue (TFC-612) improves the reduction in motor nerve conduction velocity in spontaneously diabetic GK (Goto-Kakizaki) rats
Enteric neuropeptides in streptozotocin-diabetic rats; effects of insulin and aldose reductase inhibition
Hyperglycemia-induced activation of human erythrocyte aldose reductase and alterations in kinetic properties
Interrelationships among human aldo-keto reductases: immunochemical, kinetic and structural properties
Analysis of polyols in uremic serum by liquid chromatography combined with atmospheric pressure chemical ionization mass spectrometry
The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism
The aldose reductase inhibitor sorbinil does not prevent the impairment in nitric oxide-mediated neurotransmission in anococcygeus muscle from diabetic rats
Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients
Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy
Prevention of some electrophysiologic and biochemical abnormalities with oxygen supplementation in experimental diabetic neuropathy
Glutamine: fructose-6-phosphate amidotransferase (GFAT): homology modelling and designing of new inhibitors using pharmacophore and docking based hierarchical virtual screening protocol
Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases
Overt diabetic neuropathy: repair of axo-glial dysjunction and axonal atrophy by aldose reductase inhibition and its correlation to improvement in nerve conduction velocity
Inhibitory effect of streptozotocin-induced diabetes on non-cholinergic motor transmission in rat detrusor and its prevention by sorbinil
The effects of hypoxia on the excitability of the isolated peripheral nerves of alloxan-diabetic rats
Influence of dietary myoinositol on nerve conduction and inositol phospholipids in normal and diabetic rats
Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study
Metabolic alterations in the human erythrocyte produced by increases in glucose concentration. The role of the polyol pathway
Studies on mechanisms of cerebral edema in diabetic comas. Effects of hyperglycemia and rapid lowering of plasma glucose in normal rabbits
Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats
Capillary gas chromatographic-electron-capture assay for the aldose reductase inhibitor imirestat in lens and plasma
Chiral resolution, determination of absolute configuration, and biological evaluation of (1,2-benzothiazin-4-yl)acetic acid enantiomers as aldose reductase inhibitors
Levels of expression of hexokinase, aldose reductase and sorbitol dehydrogenase genes in lens of mouse and rat
Serum antibody responses to bovine retinal S-antigen and rod outer segments in proliferative diabetic retinopathy before and after argon laser photocoagulation
Sorbitol dehydrogenase. Full-length cDNA sequencing reveals a mRNA coding for a protein containing an additional 42 amino acids at the N-terminal end
Ganglioside treatment modifies abnormal elemental composition in peripheral nerve myelinated axons of experimentally diabetic rats
Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold
Decreased endoneurial fluid electrolytes in normal rat sciatic nerve after aldose reductase inhibition
Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors
Erythrocytic sorbitol contents in diabetic patients correlate with blood aldose reductase protein contents and plasma glucose levels, and are normalized by the potent aldose reductase inhibitor fidarestat (SNK-860)
Diminished ouabain-sensitive, sodium-potassium ATPase activity in sciatic nerves of rats with streptozotocin-induced diabetes
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat
Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats
The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats
No correlation between glycemic control and an increase in erythrocyte aldose reductase activity in type I and type II diabetic patients
Slow orthograde axonal transport of radiolabelled protein in sciatic motoneurones of rats with short-term experimental diabetes: effects of treatment with an aldose reductase inhibitor or myo-inositol
Insulin reverses enhanced incorporation of 32P into polyphosphoinositides in peripheral nerve of the streptozotocin diabetic rat
Slow axonal transport of structural polypeptides in rat, early changes in streptozocin diabetes, and effect of insulin treatment
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy
A comparison between atria from control and streptozotocin-diabetic rats: the effects of dietary myoinositol
The utilization of 13C and 31P nuclear magnetic resonance spectroscopy in the study of the sorbitol pathway and aldose reductase inhibition in intact rabbit lenses
Ultrasonography of palm to elbow segment of median nerve in different degrees of diabetic polyneuropathy
Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase
Altered glutathione system is associated with the presence of distal symmetric peripheral polyneuropathy in type 2 diabetic subjects
1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase
High glucose levels induce inhibition of Na,K-ATPase via stimulation of aldose reductase, formation of microtubules and formation of an acetylated tubulin/Na,K-ATPase complex
Novel insights into metabolic sequelae of obstructive sleep apnoea: a link between hypoxic stress and chronic diabetes complications
Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: implications for brain energy metabolism and neurotrophic signaling
Three-dimensional quantitative structure-activity relationships and docking studies of some structurally diverse flavonoids and design of new aldose reductase inhibitors
Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats
Blockade of store-operated calcium entry alleviates high glucose-induced neurotoxicity via inhibiting apoptosis in rat neurons
Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy
Price for Opening the Transient Specificity Pocket in Human Aldose Reductase upon Ligand Binding: Structural, Thermodynamic, Kinetic, and Computational Analysis
Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Post-mortem evidence from human brain tissue of disturbed glucose metabolism in mood and psychotic disorders
Identification of quinoxalin-2(1H )-one derivatives as a novel class of multifunctional aldose reductase inhibitors
Diabetic polyneuropathy and the risk of developing carpal tunnel syndrome: a nationwide, population-based study
Influence of glucoregulation with continuous subcutaneous insulin infusion on nerve conduction velocity and beat to beat variation in diabetics
Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function
Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila
(5-Hydroxy-4-oxo-2-styryl-4H-pyridin-1-yl)-acetic Acid Derivatives as Multifunctional Aldose Reductase Inhibitors.
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