SORL1 Variants Show Different Association with Early-Onset and Late-Onset Alzheimer's Disease Risk

Journal of Alzheimer's Disease : JAD
Guiyou LiuBao-Liang Sun

Abstract

A recent study sequenced the full coding region of SORL1 in 1,255 early-onset Alzheimer's disease (EOAD) cases and 1,938 control individuals, and investigated the contribution of genetic variability in SORL1 to EOAD risk in a European cohort. This study identified six common variants and five low frequency variants in the SORL1 coding sequence. However, none of these 11 variants was significantly associated with EOAD risk after adjusting for multiple testing. We consider whether these 11 SORL1 variants identified in European EOAD contribute to late-onset Alzheimer's disease (LOAD) risk in individuals of European ancestry. Here, we investigated these 11 SORL1 variants identified in European EOAD and LOAD risk in individuals of European ancestry using a large-scale LOAD GWAS. Our results indicate that three genetic variants rs2070045, rs2276412, and rs17125548 as well as their tagged genetic variants contribute to LOAD risk in European population. We further investigate whether these variants could affect SORL1 expression using multiple expression quantitative trait loci (eQTLs) datasets. Our findings suggest that three genetic variants rs2070045, rs1699102, and rs3824968 could significantly regulate SORL1 expression in human bra...Continue Reading

References

Jan 16, 2007·Nature Genetics·Ekaterina RogaevaPeter St George-Hyslop
Sep 1, 2014·Nature Neuroscience·Adaikalavan RamasamyMichael E Weale
Nov 11, 2014·Annals of Neurology·Badri N VardarajanRichard Mayeux
Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Guiyou LiuRenzhi Wang
Aug 19, 2015·Annals of Neurology·Keshen LiGuiyou Liu
Dec 26, 2015·Annals of Neurology·Qinghua Jiang, Guiyou Liu
Mar 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Guiyou Liu, Qinghua Jiang
Apr 27, 2016·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Agnes PrinsEric P Moll van Charante
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Guiyou LiuJunwei Hao
Dec 31, 2016·Alzheimer's Research & Therapy·Cheng-Ta ChouJong-Ling Fuh
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Guiyou LiuQinghua Jiang

❮ Previous
Next ❯

Citations

Jul 30, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qingrong LiuHaijie Liu
Oct 15, 2019·Frontiers in Genetics·Yu YangHaining Zhang
Mar 3, 2020·Journal of Alzheimer's Disease : JAD·Haihua ZhangGuiyou Liu
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·Guiyou LiuQinghua Jiang
Jan 15, 2019·Journal of Alzheimer's Disease : JAD·Fadia El BitarNada Al Tassan
Jun 27, 2020·JAD Reports·Karissa BarthelsonMichael Lardelli
Mar 1, 2019·Current Genetic Medicine Reports·Shea J AndrewsAlison Goate
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jing-Yi SunGuiyou Liu
Jun 8, 2021·Journal of Alzheimer's Disease : JAD·Anita KorpiojaAnne M Remes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.