Sororin is a master regulator of sister chromatid cohesion and separation.

Cell Cycle
Nenggang Zhang, Debananda Pati

Abstract

The maintenance of sister chromatid cohesion from S phase to the onset of anaphase relies on a small but evolutionarily conserved protein called Sororin. Sororin is a phosphoprotein and its dynamic localization and function are regulated by protein kinases, such as Cdk1/cyclin B and Erk2. The association of Sororin with chromatin requires cohesin to be preloaded to chromatin and modification of Smc3 during DNA replication. Sororin antagonizes the function of Wapl in cohesin releasing from S to G 2 phase and promotes cohesin release from sister chromatid arms in prophase via interaction with Plk1. This review focuses on progress of the identification and regulation of Sororin during cell cycle; role of post-translational modification on Sororin function; role of Sororin in the maintenance and resolution of sister chromatid cohesion; and finally discusses Sororin's emerging role in cancer and the potential issues that need be addressed in the future.

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Citations

Feb 20, 2015·Cell Cycle·Laura A Díaz-Martínez, Duncan J Clarke
Jan 22, 2015·Cell Cycle·Nenggang Zhang, Debananda Pati
Nov 15, 2016·International Journal of Oncology·Tatsuya KatoKazuhiro Yasufuku
Jun 3, 2021·International Journal of Molecular Sciences·Nenggang ZhangDebananda Pati

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