SORS: a new software for the simulation of radiotherapy schedule

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
Pasquale TamborraEnza Carioggia

Abstract

We present a software for choosing the best radiotherapy treatment schedule for head and neck cancers as a beginning radiotherapy plan or a temporarily interrupted plan. Its application occurs according to two modalities: the first adopts the best estimates for model parameters; the second takes into account the parameters' uncertainty too. In both cases, the choice becomes the schedule with the highest uncomplicated tumor control probability (UTCP). In the UTCP valuation, the normal tissue complication probability (NTCP) of each organ is related to the gravity of its possible late injury. For NTCP calculation, it has been adopted the empirical LKB (Lyman-Kutcher-Burman) model corrected for dose/fraction via linear-quadratic model and the incomplete repair effect. The tumor control probability (TCP) model is Poisson based and contains corrections for dose/fraction and regrowth effect; optionally, it can be accounted for the incomplete repair effect as well. At the end of processing, a detailed file with all informations about UTCP, TCP and single organ NTCP is furnished for every examined schedule. Moreover, a useful 3-D graphic representation of the schedule's UTCP is available, allowing the physician to easily understand the ...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·C BurmanM Goitein
Jul 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S PowellC Parsons
Mar 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H D Thames
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·S A Roberts, J H Hendry
Feb 5, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M BentzenS Dische
Mar 4, 2000·International Journal of Radiation Oncology, Biology, Physics·D Levin-PlotnikS Akselrod
Jun 17, 2000·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·B Sanchez-Nieto, A E Nahum
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·Qiuwen WuRupert Schmidt-Ullrich
Jan 31, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·R G DaleJ A Sinclair
Nov 3, 2005·Physics in Medicine and Biology·A OlafssonS J Wright
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·X Sharon QiX Allen Li
Nov 28, 2006·International Journal of Radiation Oncology, Biology, Physics·Yusung Kim, Wolfgang A Tomé
Feb 20, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·J F Fowler
Nov 8, 2007·Medical Physics·Robert D Stewart, X Allen Li
Jan 10, 2008·Physics in Medicine and Biology·Gary LuxtonChristopher R King

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