Sortase A-Inhibitory Metabolites from a Marine-Derived Fungus Aspergillus sp.

Marine Drugs
Sung Chul ParkKi-Bong Oh

Abstract

Seven alkaloidal compounds (2-8) and one polyketide (1) were isolated from a semisolid rice culture of the marine-derived fungus Aspergillus sp. F452. Structures of the isolated compounds were elucidated based on spectroscopic data and comparisons with previously reported data. The alkaloidal compounds (2-8) displayed weak to moderate inhibitory activities against Staphylococcus aureus-derived sortase A (SrtA) without affecting cell viability. Aspermytin A (1) strongly inhibited SrtA activity, with an IC50 value of 146.0 μM, and significantly reduced bacterial adherence to fibronectin-coated surfaces. The present results indicate that the underlying mechanism of action of compound 1 is associated with the inhibition of SrtA-mediated S. aureus adhesion to fibronectin, thus potentially serving as an SrtA inhibitor.

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Citations

Dec 31, 2020·Marine Drugs·Jae Sung ParkJongheon Shin
May 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nelson G M GomesPaula B Andrade
Jul 24, 2021·Molecular Aspects of Medicine·Vinay SharmaVengadesan Krishnan
Sep 14, 2021·Journal of Medicinal Chemistry·Rachit SapraV Haridas

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Datasets Mentioned

BETA
KF384188

Methods Mentioned

BETA
NMR
Assay

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