Sortilin promotes glioblastoma invasion and mesenchymal transition through GSK-3β/β-catenin/twist pathway

Cell Death & Disease
Wei YangLiang Yi

Abstract

High aggressiveness is a hallmark of glioblastoma and predicts poor prognosis of patients with glioblastoma. The expression level of sortilin has been preliminarily reported to be elevated in high-grade glioma; however, the potential significance of sortilin in glioblastoma progression has not been elucidated. In this study, we investigated the oncogenic effect of sortilin in glioblastoma. Increased levels of sortilin were noted in the mesenchymal subtype of glioblastoma and highly aggressive subtypes of glioblastoma tissues and cell lines. In addition, high levels of sortilin predicted poor prognoses in patients with glioblastoma. Sortilin knockdown or inhibition with AF38469 (an orally bioavailable inhibitor of sortilin) significantly suppressed migration and invasion by inhibiting EMT-like mesenchymal transition in glioblastoma cells. Furthermore, we proved that sortilin promoted cell invasion mainly via Glycogen synthase kinase 3 beta (GSK-3β)/β-catenin/Twist-induced EMT-like mesenchymal transition in glioblastoma. Taken together, our results demonstrate a critical role of sortilin in glioblastoma invasion and EMT-like mesenchymal transition, indicating that sortilin contributes to glioblastoma progression. These data also ...Continue Reading

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Citations

Mar 4, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Aihua LiuLihua Liu
Feb 13, 2020·Cell Communication and Signaling : CCS·Wei YangLiang Yi
Oct 19, 2019·Biological Reviews of the Cambridge Philosophical Society·Xin Su, Daoquan Peng
Feb 9, 2021·Translational Neuroscience·Ying YangAijun Shan
Feb 27, 2021·Journal of Cellular Physiology·Fatemeh GhaemimaneshKioomars Saliminejad
Mar 26, 2021·Acta Neuropathologica Communications·Yona KimSun Ha Paek
Oct 19, 2020·Current Cancer Drug Targets·Milad AshrafizadehManoj Garg
Jun 12, 2020·The American Journal of Pathology·Fangfang GaoHubert Hondermarck

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Methods Mentioned

BETA
electrophoresis
PCR
xenografts
xenograft
surgical resection
genotyping

Software Mentioned

SPSS
pro
plus
Image
GraphPad
Image J
BoxPlot
GraphPad Prism
R2

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