Sorting the trash: Micronucleophagy gets selective

The Journal of Cell Biology
Pauline Verlhac, Fulvio Reggiori

Abstract

During micronucleophagy, the nucleolus is targeted by autophagic degradation, but although nucleolar proteins are recycled, ribosomal DNA is spared. Mostofa et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706164) reveal that the separation of these two nucleolar components is mediated by the CLIP and cohibin complexes and is vital for cell survival during starvation.

References

Jan 17, 2003·Molecular Biology of the Cell·Paul RobertsDavid S Goldfarb
Jun 25, 2009·Autophagy·Young-Eun ParkIchizo Nishino
Oct 15, 2010·Molecular Biology of the Cell·Rosie Dawaliby, Andreas Mayer
Sep 1, 2012·Nature Reviews. Drug Discovery·David C RubinszteinBeth Levine
Sep 26, 2013·Nature Reviews. Immunology·Vojo DereticShizuo Akira
Jun 10, 2017·The EMBO Journal·Lorenzo GalluzziGuido Kroemer
Apr 1, 2018·The FEBS Journal·Muhammad Arifur RahmanTakashi Ushimaru
Apr 6, 2018·Nature Reviews. Molecular Cell Biology·Ivan Dikic, Zvulun Elazar
Jul 1, 2018·The Journal of Cell Biology·Md Golam MostofaTakashi Ushimaru

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Methods Mentioned

BETA
CLIP

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