Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
David R PowellArthur T Sands

Abstract

Oral agents are needed that improve glycemic control without increasing hypoglycemic events in patients with type 1 diabetes (T1D). Sotagliflozin may meet this need, because this compound lowers blood glucose through the insulin-independent mechanisms of inhibiting kidney SGLT2 and intestinal SGLT1. We examined the effect of sotagliflozin on glycemic control and rate of hypoglycemia measurements in T1D mice maintained on a low daily insulin dose, and compared these results to those from mice maintained in better glycemic control with a higher daily insulin dose alone. Nonobese diabetes-prone mice with cyclophosphamide-induced T1D were randomized to receive one of four daily treatments: 0.2 U insulin/vehicle, 0.05 U insulin/vehicle, 0.05 U insulin/2 mg/kg sotagliflozin or 0.05 U insulin/30 mg/kg sotagliflozin. Insulin was delivered subcutaneously by micro-osmotic pump; the day after pump implantation, mice received their first of 22 once-daily oral doses of sotagliflozin or vehicle. Glycemic control was monitored by measuring fed blood glucose and hemoglobin A1c levels. Blood glucose levels decreased rapidly and comparably in the 0.05 U insulin/sotagliflozin-treated groups and the 0.2 U insulin/vehicle group compared to the 0.05...Continue Reading

Citations

Nov 10, 2015·Expert Opinion on Investigational Drugs·Bertrand Cariou, Bernard Charbonnel
Jun 20, 2018·Diabetes Technology & Therapeutics·Thomas DanneOlga Kordonouri
Nov 1, 2018·Expert Review of Endocrinology & Metabolism·Marc S Rendell
Apr 27, 2017·The Journal of Pharmacology and Experimental Therapeutics·David R PowellZhi-Ming Ding
Jul 31, 2019·Phytotherapy Research : PTR·Reyhaneh Moradi-MarjanehAmirhossein Sahebkar
Nov 8, 2019·Fundamental & Clinical Pharmacology·Jaspreet KalraArti Dhar
Jan 3, 2020·Journal of Primary Care & Community Health·Lea El HagePratibha Rao
Mar 2, 2019·Cardiovascular Diabetology·Chiara Maria Assunta CefaloAndrea Giaccari
Aug 23, 2018·Diabetologia·Rory J McCrimmon, Robert R Henry
Dec 8, 2017·Expert Opinion on Pharmacotherapy·Marc S Rendell
Nov 6, 2020·International Journal of Nephrology and Renovascular Disease·George Vasquez-Rios, Girish N Nadkarni

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