Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure.

The New England Journal of Medicine
Deepak L BhattSOLOIST-WHF Trial Investigators

Abstract

Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure or death from cardiovascular causes among patients with stable heart failure. However, the safety and efficacy of SGLT2 inhibitors when initiated soon after an episode of decompensated heart failure are unknown. We performed a multicenter, double-blind trial in which patients with type 2 diabetes mellitus who were recently hospitalized for worsening heart failure were randomly assigned to receive sotagliflozin or placebo. The primary end point was the total number of deaths from cardiovascular causes and hospitalizations and urgent visits for heart failure (first and subsequent events). The trial ended early because of loss of funding from the sponsor. A total of 1222 patients underwent randomization (608 to the sotagliflozin group and 614 to the placebo group) and were followed for a median of 9.0 months; the first dose of sotagliflozin or placebo was administered before discharge in 48.8% and a median of 2 days after discharge in 51.2%. Among these patients, 600 primary end-point events occurred (245 in the sotagliflozin group and 355 in the placebo group). The rate (the number of events per 100 patient-years) of primary end...Continue Reading

References

Sep 15, 1994·Statistics in Medicine·T A StukelJ E Wennberg
Apr 12, 2000·Journal of the American College of Cardiology·C P GreenJ A Spertus
Jan 13, 2006·JAMA : the Journal of the American Medical Association·Deepak L BhattUNKNOWN REACH Registry Investigators
Mar 22, 2007·JAMA : the Journal of the American Medical Association·Ph Gabriel StegUNKNOWN REACH Registry Investigators
Sep 2, 2010·JAMA : the Journal of the American Medical Association·Deepak L BhattUNKNOWN REACH Registry Investigators
Oct 12, 2010·The New England Journal of Medicine·Deepak L BhattUNKNOWN COGENT Investigators
Sep 3, 2013·The New England Journal of Medicine·Benjamin M SciricaUNKNOWN SAVOR-TIMI 53 Steering Committee and Investigators
Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
Feb 6, 2016·Journal of the American College of Cardiology·Tannas JateneUNKNOWN CHAMPION PHOENIX Investigators
Jun 13, 2017·The New England Journal of Medicine·Bruce NealUNKNOWN CANVAS Program Collaborative Group
Sep 14, 2017·The New England Journal of Medicine·Satish K GargPaul Strumph
Aug 1, 2018·JACC. Basic to Translational Science·Stephen E ShermanSubodh Verma
Sep 29, 2018·Canadian Journal of Physiology and Pharmacology·Naresh KumarSubodh Verma
Nov 10, 2018·Journal of the American College of Cardiology·Muthiah VaduganathanDeepak L Bhatt
Nov 13, 2018·The New England Journal of Medicine·Stephen D WiviottUNKNOWN DECLARE–TIMI 58 Investigators
Dec 6, 2018·Cell Metabolism·Kim A ConnellySubodh Verma
Jan 31, 2019·Lifetime Data Analysis·Per Kragh AndersenHenrik Ravn
Apr 17, 2019·The New England Journal of Medicine·Vlado PerkovicUNKNOWN CREDENCE Trial Investigators
Jun 12, 2019·Circulation·Subodh Verma, Deepak L Bhatt
Sep 20, 2019·The New England Journal of Medicine·John J V McMurrayUNKNOWN DAPA-HF Trial Committees and Investigators
Nov 7, 2019·Cell Metabolism·Deepak L BhattEugene Braunwald
Dec 15, 2019·The Journal of Clinical Endocrinology and Metabolism·David R PowellPablo Lapuerta
Jan 26, 2020·Biochemical and Biophysical Research Communications·Biswajit ChowdhuryDavid A Hess
Mar 12, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Erika OpingariRichard E Gilbert
May 30, 2020·Journal of the American College of Cardiology·Emilia BagiellaMario Gaudino
Jul 28, 2020·Journal of the American Heart Association·Senthil SelvarajDeepak L Bhatt
Aug 4, 2020·Journal of the American College of Cardiology·Mario GaudinoEmilia Bagiella
Sep 1, 2020·The New England Journal of Medicine·Milton PackerUNKNOWN EMPEROR-Reduced Trial Investigators
Sep 3, 2020·Nature Reviews. Cardiology·Prakriti Gaba, Deepak L Bhatt
Sep 24, 2020·The New England Journal of Medicine·Christopher P CannonUNKNOWN VERTIS CV Investigators
Sep 25, 2020·The New England Journal of Medicine·Hiddo J L HeerspinkUNKNOWN DAPA-CKD Trial Committees and Investigators

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Citations

Nov 26, 2020·Nature Reviews. Cardiology·Andrew Robson
Dec 1, 2020·European Journal of Heart Failure·Milton PackerUNKNOWN EMPEROR Trial Committees and Investigators
Nov 29, 2020·European Journal of Heart Failure·Ankeet S Bhatt, Muthiah Vaduganathan
Dec 6, 2020·ESC Heart Failure·Daniela TomasoniMarco Metra
Jan 4, 2021·European Heart Journal·Héctor BuenoJohann Bauersachs
Feb 14, 2021·Cardiovascular Research·Kanako TeramotoCarolyn S P Lam
Jan 15, 2021·International Journal of Molecular Sciences·María Aguilar-BallesterHerminia González-Navarro
Jan 27, 2021·The New England Journal of Medicine·Frank C Brosius, Per O Vandvik
Dec 29, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Gianluigi Savarese
Feb 7, 2021·European Journal of Heart Failure·Gad CotterAlexandre Mebazaa
Jan 17, 2021·The Canadian Journal of Cardiology·Robert J H MillerNowell M Fine
Mar 9, 2021·Endocrinology and Metabolism·Eun-Jung RheeWon-Young Lee
Mar 17, 2021·Circulation. Heart Failure·John A SpertusJohn Whang
Mar 20, 2021·Journal of the American College of Cardiology·Mikhail N Kosiborod, Muthiah Vaduganathan
Mar 27, 2021·Current Opinion in Nephrology and Hypertension·Caitlyn VlasschaertSamuel A Silver
Apr 1, 2021·The New England Journal of Medicine·Rita R Kalyani
Apr 2, 2021·Cardiovascular Diabetology·Oliver SchnellEberhard Standl
Mar 29, 2021·Néphrologie & thérapeutique·Jean-Michel Halimi
Mar 31, 2021·Metabolism Open·Natalia G VallianouMaria Dalamaga
Mar 30, 2021·European Journal of Heart Failure·Vibhu Parcha, Pankaj Arora
Mar 30, 2021·European Journal of Heart Failure·Muhammad Shahzeb KhanStephen J Greene
Apr 6, 2021·Diabetes & Metabolism Journal·Jin Joo Park
Apr 6, 2021·Diabetes & Metabolism Journal·Jia Shen, Barry H Greenberg
Apr 13, 2021·Advances in Therapy·Aileen KearneyIan B A Menown
Apr 15, 2021·The New England Journal of Medicine·Deepak L BhattBertram Pitt
Apr 11, 2021·European Journal of Internal Medicine·Angelo Avogaro

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