Sound exposure-induced cytokine gene transcript profile changes in captive bottlenose dolphin (Tursiops truncatus) blood identified by a probe-based qRT-PCR

The Journal of Veterinary Medical Science
I-Hua ChenWei Cheng Yang

Abstract

Cetacean health may be potentially affected by anthropogenic sound. We have initiated investigations on the effect of low-frequency underwater sound on immunological gene transcript profiles of captive bottlenose dolphins (Tursiops truncatus) using a probe-based quantitative gene expression assay. Six immunologic genes (IL-2Rα, -4, -10, -12, TNFα and IFNγ) were selected for analysis using two validated housekeeping genes (PGK1 and HPRT1) as reference genes. Twenty-four blood samples from six clinically healthy individuals and six blood samples from individuals after sound exposures were available. The gene transcript profile of sound-exposed dolphins was consistent with a stress-induced TH2 shift profile as compared to controls. This study may lead to better understanding of the effects of anthropogenic sound on immune responses of cetaceans.

References

Aug 12, 2003·Trends in Immunology·David A Padgett, Ronald Glaser
Apr 9, 2005·Genes and Immunity·J HuggettA Zumla
Oct 24, 2006·Veterinary Immunology and Immunopathology·Andreas BeinekeWolfgang Baumgärtner
May 12, 2007·Cytokine & Growth Factor Reviews·Ian A Clark
Feb 27, 2008·Nature Immunology·Caroline L SokolRuslan Medzhitov
Jun 24, 2008·Developmental and Comparative Immunology·Tatjana SittJeffrey L Stott
Jan 24, 2009·Immunological Reviews·David M Mosser, Xia Zhang
Sep 30, 2009·BMC Immunology·Wilco de JagerVicki Seyfert-Margolis
Jun 29, 2010·Veterinary Immunology and Immunopathology·Tatjana SittJeffrey L Stott
Oct 12, 2011·Environmental Science & Technology·Andrea H BuckmanPeter S Ross
Oct 23, 2013·Marine Environmental Research·Ronald A KasteleinLean Hoek
Feb 28, 2014·Journal of the American Heart Association·Anandwardhan A HardikarMugdha V Joglekar
May 6, 2015·Journal of Visualized Experiments : JoVE·Wilson WongAnandwardhan Hardikar
Jun 9, 2016·Veterinary Immunology and Immunopathology·Tatjana SittJeffrey L Stott

❮ Previous
Next ❯

Citations

Sep 5, 2019·Frontiers in Immunology·Sylvain De GuiseRandall S Wells
Nov 15, 2019·Behavioral Ecology : Official Journal of the International Society for Behavioral Ecology·Harry R HardingAndrew N Radford
Jun 19, 2020·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Amelia R HofstetterRandy E Sacco

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
RNA Assay
PCR
reverse
biopsies

Software Mentioned

Eco
Geomean

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.