Source and function of keto elaidic acids from lungs of cotton workers

Archives of Environmental Health
W S LynnN G Phillips

Abstract

A series of cytotoxic oxygenated derivatives of oleic acid, 8-oxo-9, 9-oxo-10, 10-oxo-8-, and 11-oxo-9 trans octadecenoic acid, uniquely found at post-mortem in airway cells of cotton workers, were synthesized and shown to be cytotoxic, i.e., inhibitory of growth for several cell lines, including HL-60 and U-937 promyelocytes and Eagle's KB carcinoma cells. At microM concentrations, the 8- and 11- keto acids: are chemokinetic for human neutrophils; activate production of O2-. and H2O2; stimulate promyelocytes in culture to differentiate into neutrophils; and increase diglyceride metabolism in inflammatory cells. These results indicate that these four monooxygenated fatty acids, which are found in airways of cotton workers and initiate both inflammation and differentiation in vitro, may be etiologic in the abnormal differentiation and inflammation seen in small airways of cotton workers. This abnormal differentiation in bronchi may result from altered diglyceride metabolism with resultant activation of phosphoprotein kinase C initiated by the keto fatty acids.

References

Jan 3, 1978·Biochimica Et Biophysica Acta·K Kakinuma, S Minakami
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J G EbelingJ E Niedel
May 1, 1985·Archives of Environmental Health·T G Mundie, S K Ainsworth
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C N SerhanB Samuelsson
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J E NiedelG R Vandenbark
Jan 1, 1984·American Journal of Epidemiology·G J BeckE N Schachter
Dec 5, 1980·Biochimica Et Biophysica Acta·B A Freeman, W S Lynn

❮ Previous
Next ❯

Citations

May 1, 1990·The American Review of Respiratory Disease·C W SachsW S Lynn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.