PMID: 11325463Apr 28, 2001Paper

Source localisation of 62-electrode human laser pain evoked potential data using a realistic head model

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
Deborah E BentleyA K Jones

Abstract

Laser evoked potentials (LEPs), elicited by painful laser stimulation of the right forearm, were recorded from 62 electrodes in a single healthy subject. The positions of the electrodes on the scalp were co-registered with the subject's structural magnetic resonance image (MRI) of the brain. Spatio-temporal dipole modelling, using a head model derived from the MRI, estimated sources in left posterior cingulate, posterior parietal and anterior insular cortices. The parietal source peaked in activity at 260 ms, which explained the N1/N2 peaks of the LEPs. The cingulate source was the most strongly activated, at 400 ms, and accounted for the P2 LEP component. The insular source showed late, prolonged activation, peaking in magnitude at 850 ms. This is the first study to report scalp-recorded LEP generators in posterior parietal and insular cortices. Although these sources require replication, they are consistent with other functional imaging studies.

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Citations

Mar 24, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yunhai QiuRyusuke Kakigi
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·L Garcia-LarreaM Valeriani
Jan 26, 2002·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Luis Garcia-Larrea
Jul 26, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D E BentleyA K P Jones
Oct 28, 2004·Behavioral Neuroscience·Claudio BabiloniAndrew C N Chen
Apr 28, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shiyun ShaoXiaoping Li
Dec 21, 2006·NeuroImage·Christoph ChristmannHerta Flor
May 1, 2009·Expert Review of Neurotherapeutics·Costanza Pazzaglia, Massimiliano Valeriani
Mar 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ryusuke KakigiYohei Tamura
Mar 31, 2009·NeuroImage·Raffaella FranciottiGian Luca Romani
Nov 16, 2017·European Journal of Pain : EJP·K EcsyA K P Jones
Aug 21, 2009·Journal of Neurophysiology·Valéry LegrainLuis García-Larrea
Sep 1, 2017·Scientific Reports·Etienne AllardThomas Similowski
Nov 5, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jennifer A ClarkWael El-Deredy

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