Source localization of small sharp spikes: low resolution electromagnetic tomography (LORETA) reveals two distinct cortical sources

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Dominik ZumstegRichard A Wennberg

Abstract

We have investigated the cortical sources and electroencephalographic (EEG) characteristics of small sharp spikes (SSS) by using statistical non-parametric mapping (SNPM) of low resolution electromagnetic tomography (LORETA). We analyzed 7 SSS patterns (501 individual SSS) in 6 patients who underwent sleep EEG studies with 29 or 23 scalp electrodes. The scalp signals were averaged time-locked to the SSS peak activity and subjected to SNPM of LORETA values. All 7 SSS patterns (mean 72 individual SSS, range 11-200) revealed a very similar and highly characteristic transhemispheric oblique scalp voltage distribution comprising a first negative field maximum over ipsilateral lateral temporal areas, followed by a second negative field maximum over the contralateral subtemporal region approximately 30 ms later. SNPM-LORETA consistently localized the first component into the ipsilateral posterior insular region, and the second component into ipsilateral posterior mesial temporo-occipital structures. SSS comprise an amalgam of two sequential, distinct cortical components, showing a very uniform and peculiar EEG pattern and cortical source solutions. As such, they must be clearly distinguished from interictal epileptiform discharges in ...Continue Reading

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Citations

Oct 7, 2008·Applied Psychophysiology and Biofeedback·Rex CannonDebora Baldwin
Feb 26, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B ClemensK Hollódy
Apr 21, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masako TamakiTadao Hori
Mar 7, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Verena BrodbeckChristoph M Michel
Jan 17, 2008·Journal of Veterinary Internal Medicine·Janis JeserevicsLuciana Bergamasco
Feb 14, 2015·Social Cognitive and Affective Neuroscience·Philip A GableDavid L Adams
May 12, 2012·Neuroscience Letters·Rex L CannonTimothy C Riehl
Jan 7, 2020·The International Journal of Neuroscience·Mojtaba JouzizadehAmir Hossein Ghaderi
Oct 8, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Naoum P Issa, James X Tao
Sep 30, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Richard WennbergLuis Garcia Dominguez
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Nino EpitashviliAndreas Schulze-Bonhage

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