PMID: 9533824Jun 1, 1997Paper

Source of ATP, ADP, AMP and adenosine released from isolated rat caudal artery exposed to noradrenaline

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
M HashimotoS Masumura

Abstract

Purines of ATP, ADP, AMP and adenosine released from rat caudal artery with and without endothelium and the isolated smooth muscle and endothelial cells were examined, in order to determine the source. Treatment of intact segments of caudal arteries with noradrenaline (10 microM) for 3 min induced a large release of ATP, ADP, AMP and adenosine. However, if the artery segments had been denuded of their endothelial lining, noradrenraline induced only a slight release of purines. Endothelial cells in primary culture prepared from caudal arteries, when exposed to noradrenaline for 3 min released large amounts of purines, whereas vascular smooth muscle cells prepared similarly and passaged endothelial cells did not release purines upon exposure to noradrenaline. These results indicate that, of smooth muscle and endothelial cells of the vascular wall, only intact endothelial cells react to alpha-adrenoceptor stimulation by releasing adenine nucleotides and adenosine.

Citations

Jun 30, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Louis CarregaRégis P Guieu
Apr 12, 2000·Acta Physiologica Scandinavica·G Rådegran, Y Hellsten
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic

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